Major trial aims to settle best approach for precancerous esophagus condition

NCT ID NCT05753748

Recruiting now Disease control Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two standard approaches for Barrett's esophagus with low-grade dysplasia: regular monitoring with biopsies (surveillance) versus a procedure to remove or burn away precancerous cells (endoscopic eradication therapy). Researchers want to find out which method is safer and more effective at preventing progression to cancer. About 680 adults with this condition will take part across multiple U.S. hospitals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Endoscopic eradication therapy (removal or burning of precancerous cells) and endoscopic surveillance (biopsy monitoring)
What this could lead to: If successful, this trial could show that one approach is safer and more effective at preventing esophageal cancer in people with Barrett's esophagus and low-grade dysplasia.
What could go wrong: This is a large, well-designed trial, but low-grade dysplasia often does not progress to cancer, so the benefit of aggressive treatment may be small. Endoscopic therapy also carries risks like bleeding or narrowing of the esophagus.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus Barrett esophagus esophageal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT ESOPHAGUS BARRETTS ESOPHAGUS WITH DYSPLASIA ESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Locations

Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia Universtiy
RECRUITING

New York, New York, 10032, United States
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Florida Digestive Health Specialists
RECRUITING

Sarasota, Florida, 34239, United States
Indiana University Melvin & Bren Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Johns Hopkins Universtiy
RECRUITING

Baltimore, Maryland, 21205, United States
Kaiser Permanente
RECRUITING

San Jose, California, 95119, United States
Kaiser Permanente Oakland Medical Center
RECRUITING

Oakland, California, 94611, United States
Long Island Jewish Medical Center
RECRUITING

Manhasset, New York, 11030, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University Hospitals Cleveland Medical Center Case Western University
RECRUITING

Cleveland, Ohio, 44106, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of North Carolina School of Medicine
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Pennsylania, Perelman School of Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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