Pill-Sized device could replace endoscopy for esophageal cancer risk
NCT ID NCT03830801
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tests a new swallowable capsule that uses optical coherence tomography (OCT) to take detailed images of the esophagus and collect targeted tissue samples from areas of concern in people with Barrett's esophagus. The goal is to see if this less invasive method can provide enough tissue for genomic analysis to better predict the risk of developing esophageal cancer. The study involves 30 participants and focuses on the feasibility of the technique.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IVLCM tethered capsule (device)
What this could lead to
If successful, this could lead to a less invasive way to collect tissue samples from Barrett's esophagus, potentially improving early detection of esophageal cancer risk without the need for traditional endoscopy.
What could go wrong
This is a very early pilot study with only 30 participants, so it is not yet proven to work in practice. The technology may not reliably collect enough tissue for analysis, and results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••