Could a fungal drug stop esophageal cancer before it starts?
NCT ID NCT06732388
First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 5 times
Summary
This study tests whether adding the antifungal drug itraconazole to standard ablation therapy can prevent esophageal cancer in people with high-risk Barrett's esophagus. About 64 participants will receive either itraconazole or a placebo alongside their usual endoscopic ablation. The goal is to see if the drug helps eliminate precancerous tissue faster and reduces the chance of cancer developing.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Baylor University Medical Center
NOT_YET_RECRUITINGDallas, Texas, 75246, United States
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Case Western Reserve University
NOT_YET_RECRUITINGCleveland, Ohio, 44106, United States
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UNC Lineberger Comprehensive Cancer Center
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Kansas Cancer Center
NOT_YET_RECRUITINGKansas City, Kansas, 66160, United States
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University of Michigan Rogel Cancer Center
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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Other studies related to the condition(s) this trial covers.
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