Magic mushroom therapy takes on depression

NCT ID NCT06303739

First seen Apr 13, 2026 · Last updated May 16, 2026 · Updated 6 times

Summary

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults with treatment-resistant depression will receive one or two psilocybin sessions and be followed for a year. Researchers will track symptom changes using questionnaires to see how well and how long the treatment works.

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Contacts and locations

Locations

  • UNC Chapel Hill Medical Center

    Chapel Hill, North Carolina, 27514, United States

Conditions

Explore the condition pages connected to this study.