Magic mushroom therapy takes on tough depression

NCT ID NCT06303739

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults will receive one or two doses and be followed for a year to see if their symptoms get better and how long any improvement lasts. The goal is to ease depression symptoms, not to cure the condition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UNC Chapel Hill Medical Center

    Chapel Hill, North Carolina, 27514, United States