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Brain zaps guided by scans: a new hope for untreatable depression?

NCT ID NCT03952962

Recruiting now Disease control Sponsor: Nader Pouratian Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study tests a new way to perform deep brain stimulation (DBS) for people with severe depression that hasn't improved with standard treatments. Instead of targeting a fixed brain region, the researchers use advanced MRI scans to tailor the stimulation to each person's brain network. The goal is to see if this personalized approach is safe and can reduce depression symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
deep brain stimulation using the Abbott Laboratories Infinity™ implantable system
What this could lead to
If successful, this approach could offer a more precise and effective way to treat severe depression that hasn't responded to other therapies.
What could go wrong
This is a small, early feasibility study, so results may not apply broadly. Deep brain stimulation carries surgical risks and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION UNDERGOING DEEP BRAIN STIMULATION (DBS) SURGERY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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