New pill could stop PTSD before it starts after car crashes

NCT ID NCT06636786

Recruiting now Symptom relief Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a sublingual tablet (TNX-102 SL) can reduce acute stress symptoms and prevent long-term PTSD in adults who come to the emergency room after a car crash. 180 participants will receive either the drug or a placebo for two weeks, starting in the ER. Researchers will track stress levels, thinking abilities, and side effects over time.

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Conditions

The condition(s) this trial relates to.

acute stress disorder Stress Disorders, Traumatic, Acute post-traumatic stress disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE STRESS DISORDER ACUTE STRESS REACTION NEUROCOGNITIVE FUNCTION POST TRAUMATIC STRESS

Contacts and locations

Locations

Cooper University Health System
RECRUITING

Camden, New Jersey, 08103, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
The Miriam Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
University of Alabama at Birmingham
NOT_YET_RECRUITING

Birmingham, Alabama, 35294, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Texas Health Science Center at San Antonio
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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