Shorter PTSD therapy may be just as effective for veterans

NCT ID NCT05789329

Ongoing Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Trauma Informed Guilt Reduction Therapy (TrIGR) and Cognitive Processing Therapy (CPT)
What this could lead to: If TrIGR works as well as CPT, it could offer a shorter, less resource-heavy option for treating PTSD in Veterans.
What could go wrong: This is a non-inferiority trial with 160 participants, so results may not apply to all Veterans. The therapy is behavioral, so individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

injury post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PTSD

Contacts and locations

Locations

James A. Haley Veterans' Hospital, Tampa, FL

Tampa, Florida, 33612, United States
VA San Diego Healthcare System, San Diego, CA

San Diego, California, 92161-0002, United States

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