Could a 7-Day pill ease PTSD in veterans?

NCT ID NCT04452500

Recruiting now Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called CORT108297, which blocks the stress hormone cortisol, as a short-term treatment for PTSD in veterans. Forty veterans with PTSD will take either the drug or a placebo daily for one week. The goal is to see if it reduces PTSD symptoms and to check its safety for future, larger studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CORT108297 (a drug that blocks the hormone cortisol)
What this could lead to: If it works, this could point toward a new short-term treatment to ease PTSD symptoms in veterans.
What could go wrong: This is a small, early-phase trial with only 40 participants and a 7-day treatment. It may not show clear benefits, and safety is still being established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PTSD

Contacts and locations

Locations

San Francisco VA Medical Center, San Francisco, CA
RECRUITING

San Francisco, California, 94121-1563, United States
Tuscaloosa VA Medical Center, Tuscaloosa, AL
RECRUITING

Tuscaloosa, Alabama, 35404, United States

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