Could a blood pressure pill ease PTSD?

NCT ID NCT07499440

Recruiting now Disease control Sponsor: HB BioTech, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This Phase 2 trial is testing whether HB-1, a tablet combining two blood pressure medications (telmisartan and verapamil), can safely reduce PTSD symptoms. About 200 adults aged 18-65 with PTSD will receive either HB-1 or a placebo daily for 12 weeks. The main goal is to see if HB-1 improves clinician-rated PTSD symptoms compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HB-1 (a combination of telmisartan and verapamil in a single tablet)
What this could lead to: If successful, HB-1 could offer a new oral treatment option to reduce PTSD symptoms, potentially improving daily functioning for people with this condition.
What could go wrong: This is a Phase 2 trial with 200 participants, so results are still early. The drug may not prove more effective than placebo, and side effects from the blood pressure medications (telmisartan/verapamil) are possible.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENTAL ILLNESS PTSD

Contacts and locations

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Locations

East Sydney Doctors
RECRUITING

Darlinghurst, New South Wales, 2010, Australia

Contact Email: •••••@•••••
Innovate Clinical Research
RECRUITING

Waitara, New South Wales, 2077, Australia
Mackay Hospital and Health Service
NOT_YET_RECRUITING

Mackay, Queensland, 4740, Australia
Monash Alfred Psychiatry Research Centre
RECRUITING

Melbourne, Victoria, 3004, Australia
NeuroCentrix
NOT_YET_RECRUITING

Carlton, Victoria, 3053, Australia
Novatrials
RECRUITING

Charlestown, New South Wales, 2290, Australia
Paratus Clinical Research Brisbane
RECRUITING

Herston, Queensland, 4006, Australia
Paratus Clinical Research Canberra
RECRUITING

Bruce, Australian Capital Territory, 2617, Australia
Paratus Clinical Research Melbourne
RECRUITING

Northcote, Victoria, 3070, Australia

Contact Email: •••••@•••••
Peninsula Therapeutic and Research Group
RECRUITING

Frankston, Victoria, 3199, Australia
Ramsay Clinic Albert Road
RECRUITING

Melbourne, Victoria, 3004, Australia
South Australian Health and Medical Research Institute
RECRUITING

Adelaide, South Australia, 5000, Australia
University of the Sunshine Coast Clinical Trials, Morayfield
RECRUITING

Morayfield, Queensland, 4506, Australia
University of the Sunshine Coast Clinical Trials, Sippy Downs
RECRUITING

Sippy Downs, Queensland, 4556, Australia
WSLHD Mental Health Services, Westmead Hospital
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia

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