Exercise after fear training boosts PTSD recovery in new study
NCT ID NCT07548125
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether different levels of exercise can help people with PTSD remember fear-reduction lessons better. 200 adults with PTSD will do a 3-day fear learning and extinction task, then either rest or do light, moderate, or high-intensity exercise. The goal is to see if exercise strengthens the brain's ability to hold onto safety memories, which could improve exposure therapy outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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May 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 - 55 years of age * Currently experiencing at least 4 PTSD symptoms with at least 1 re-experiencing symptom (e.g., trauma memory intrusion, trauma nightmares, trauma flashbacks, intense emotional distress related to trauma, or marked physiological reactivity related to trauma) from criterion B. * English speaking * Medically healthy Exclusion Criteria: * being pregnant * having a history of light headedness or fainting during physical activity * having a history of chest pain during physical activity * having a bone, joint, cardiac, or other medical condition that a doctor has said may be worsened by physical activity * responding 'Yes' to any of the seven questions on the Physical Activity Readiness Questionnaire (PAR-Q; unless they provide a doctor's note indicating that it is safe for them to engage in aerobic exercise ) * percutaneous coronary intervention or acute myocardial infarction in the last 6 weeks * unstable arrhythmias/implanted cardiac defibrillator shocks in the last 3 months * Internal ferromagnetic objects (such as electronic devices, surgical implants, shrapnel, etc.) * Nonremovable dental implants, such as braces or upper permanent retainers, as these will distort the MRI images we collect (note: filings, crowns, and silver or gold teeth are OK) * Any other condition, medication, or implant that the investigator believes would degrade image quality or render data unusable * psychotic disorders * Permanent makeup or tattoos with metallic dyes, * A self-reported history of loss of consciousness (greater than 30 minutes) * physical disabilities that prohibit task performance (such as blindness or deafness) * Any other condition that the investigator believes might put the participant at risk * Claustrophobia * History of cardiovascular disease * on-going traumatic event exposure (e.g., living with an abusive partner) * Severe substance use disorder. * unstable medication (changes within the past \~4 weeks) * Acute sedatives/pain killers (e.g., benzodiazepines, Vicodin) and prescription stimulants (e.g., Adderall) would not be permitted for 6 hours prior to the study visit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Health Discovery Building
RECRUITINGAustin, Texas, 78712, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can brain stimulation unlock the secret to erasing fear?
- Zapping the Brain's fear hub: a new hope for PTSD?
- Can a drug combo or therapy dogs ease PTSD?
- Can six short writing sessions ease PTSD in underserved patients?
- Can a psychedelic compound help veterans and first responders with PTSD and alcohol use disorder?