Can a Stepped-Care approach make PTSD therapy more effective?
NCT ID NCT05457985
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This trial tests whether starting PTSD treatment with one type of talk therapy and then switching to another based on early progress leads to better symptom relief. About 430 adults receiving care at federally qualified health centers will take part. The study compares different sequences of prolonged exposure therapy and cognitive processing therapy to see which approach works best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
talk therapy (prolonged exposure for primary care and cognitive processing therapy)
What this could lead to
If successful, this could point toward a more efficient, personalized approach to PTSD treatment that uses fewer resources while still reducing symptoms.
What could go wrong
This is a behavioral intervention study, so results depend on participant engagement and may not apply to all PTSD patients. The therapies may not work better than standard care.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cherry Health
RECRUITINGGrand Rapids, Michigan, 49503, United States
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CommUnityCare Health Centers
RECRUITINGAustin, Texas, 78702, United States
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Family Care Health Centers
RECRUITINGSt Louis, Missouri, 63111, United States
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Family Health Care
TERMINATEDBaldwin, Michigan, 49304, United States
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Family Medical Center of Michigan
RECRUITINGMonroe, Michigan, 48162, United States
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Genesee Community Health Center
RECRUITINGFlint, Michigan, 48503, United States
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Grace Health
RECRUITINGBattle Creek, Michigan, 49037, United States
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Hamilton Community Health Network
RECRUITINGFlint, Michigan, 48503, United States
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MidMichigan Community Health Services
RECRUITINGHoughton Lake, Michigan, 48629, United States
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Sterling Area Health Center
RECRUITINGSterling, Michigan, 48659, United States
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Unity Care NW
RECRUITINGBellingham, Washington, 98225, United States
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Upper Great Lakes Family Health Care Center
RECRUITINGMenominee, Michigan, 49858, United States
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Western North Carolina Community Health Services
RECRUITINGAsheville, North Carolina, 28801, United States
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Contact