Exercise may soothe PTSD-Linked heart risks, tiny study hints

NCT ID NCT07260032

Recruiting now Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will use advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in 10 people with PTSD who also have heart disease or risk factors. Participants will follow a gradually increasing exercise program. The goal is to understand whether exercise can reduce artery inflammation, which is a key driver of heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exercise program
What this could lead to: If successful, this could show that exercise reduces artery inflammation in people with PTSD, pointing toward a non-drug way to lower heart disease risk.
What could go wrong: This is a very small early study with only 10 participants, so results may not apply to everyone. It is designed to gather information, not to prove a treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerotic cardiovascular disease cardiovascular disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE CARDIOVASCULAR DISEASE RISK FACTORS PTSD

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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