Scientists probe why Weight-Loss surgery causes dangerous sugar drops

NCT ID NCT02823665

Recruiting now Knowledge-focused Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at how gastric bypass and sleeve gastrectomy affect blood sugar control after eating. Researchers will give two drugs—Exendin-(9-39) and atropine—to understand the roles of hormones and nerves. The goal is to learn why some patients develop low blood sugar after surgery. The study involves 200 people, including those with and without post-surgery hypoglycemia, plus healthy volunteers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exendin-(9-39) and Atropine
What this could lead to: If successful, this could reveal why some people develop low blood sugar after bariatric surgery and point toward better management strategies.
What could go wrong: This is an early-phase observational study, not a treatment trial. Results may not lead to new therapies, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dumping syndrome hypoglycemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC BYPASS HYPOGLYCEMIA AFTER GASTRIC BYPASS POST-BARIATRIC SURGERY SLEEVE GASTRECTOMY

Contacts and locations

Locations

South Texas Veterans Health Care System
RECRUITING

San Antonio, Texas, 78229, United States
Texas Diabetes Institute - University Health System
RECRUITING

San Antonio, Texas, 78207, United States

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