The University Of Texas Health Science Center At San Antonio

This study is checking if the weight-loss drug tirzepatide causes older adults to lose too much muscle along with fat, which could lead to weakness. Researchers will give 20 obese adults over age 50 tirzepatide for six months and measure their muscle mass, strength, and walking a…

This early-stage trial is testing whether adding an experimental drug called avasopasem to standard breast cancer therapy is safe and might help when the initial treatment stops working. The study will enroll about 35 women with metastatic, hormone receptor-positive breast cancer…

This small, early-stage study is testing whether a ketone supplement drink can improve heart function in people who have both type 2 diabetes and a specific type of heart failure. Researchers will give 10 participants the supplement and use heart scans and blood tests to see if i…

This study is testing a non-invasive brain stimulation treatment called IR-TMS to see if it can help people with alcohol use disorder reduce their drinking and cravings. Participants receive multiple magnetic stimulation sessions targeting specific brain areas, along with brain s…

This early-stage study aims to find safe and effective doses of two drugs, rapamycin and everolimus, for healthy adults aged 65-90. Researchers want to see if these drugs can safely reduce a specific cellular activity linked to aging to levels seen in young, healthy people. The s…

This study is testing a new therapy designed specifically for military veterans and service members who have both post-traumatic stress disorder (PTSD) and a traumatic brain injury. The treatment involves individual counseling sessions that focus on managing PTSD symptoms without…

This study is testing if applying a special protein gel (Enamel Matrix Derivatives) during a routine dental implant procedure helps create thicker, more robust gum tissue around the implant. Researchers will compare gum thickness in 32 adults who receive the gel versus those who …

This study aims to find out which of two different two-drug combinations works better for controlling blood sugar in people recently diagnosed with type 2 diabetes. It will compare a newer combination (pioglitazone + tirzepatide) against a standard one (metformin + sitagliptin) i…

This study aims to help veterans with PTSD who aren't improving with their first treatment. Researchers will test whether switching to a different therapy approach or using text message reminders for homework assignments works better. The goal is to find the right treatment combi…

This study is testing if adding a specific neck injection, called a stellate ganglion block, to an intensive two-week therapy program works better for reducing PTSD symptoms than the therapy program alone. It will involve 140 active duty or retired military service members diagno…

This study is testing if using a high-magnification digital microscope during gum surgery leads to better healing than the current standard tool, magnifying loupes. Researchers will compare healing in 25 adults who need surgery for gum disease. Each participant will have one inci…

This study is testing whether the medication dupilumab can help control asthma symptoms triggered by house dust mite allergies. Researchers will expose 88 adult participants with this type of asthma to controlled amounts of dust mites in a special chamber to measure their reactio…

This study is testing whether a combination of two immunotherapy drugs (tremelimumab and durvalumab) is safe and effective for people with advanced liver cancer who also have moderately impaired liver function, known as Child-Pugh B cirrhosis. It focuses on including patients fro…

This study is testing whether a drug called rapamycin, taken daily for a year, is safe and might help slow down memory and thinking problems in older adults with early-stage Alzheimer's disease or mild cognitive impairment. Researchers will enroll 40 participants to measure chang…

This study compares two different bone graft materials used after tooth extraction to help preserve jawbone for future dental implants. Researchers will measure how much new bone forms in the tooth socket after about 16 weeks of healing. The study involves 44 adults who need a si…

This study aims to find affordable ways to stop prediabetes from progressing to full diabetes and reduce heart disease risk in Hispanic adults. Researchers will test four different 6-month drug combinations, including some common diabetes medications, alongside nutritional counse…

This study is testing whether taking amino acid supplements during dialysis treatments can help reduce severe fatigue and improve strength and thinking skills in people with kidney failure. Researchers will compare two different supplement formulas in about 28 patients who receiv…

This study is testing whether using the Calm meditation app for 10 minutes a day can help people with blood cancers who have trouble sleeping. Researchers will enroll 276 patients to see if the app improves sleep quality, reduces fatigue and anxiety, and lowers body inflammation …

This study is testing if wearing tight cuffs on the thighs during balance-challenging exercises can help improve symptoms for people with Parkinson's disease. Researchers want to see if this approach is safe and can improve walking, balance, and leg strength. The study will compa…

This study aims to find out which of two existing medications works better for reducing distressing hallucinations and delusions in people with Parkinson's disease or Lewy body dementia. It will compare pimavanserin and quetiapine in about 94 patients who need to start treatment …

This study is testing whether sitting in a special bathtub that uses low-frequency ultrasound waves can help older adults age more healthily. Twenty participants aged 70 and older will either sit in the ultrasound bath or a regular bath three times a week for eight weeks. Researc…

This small study is testing whether a daily, at-home brain stimulation treatment is safe and practical for people with Huntington's disease. Researchers want to see if this non-invasive therapy can help improve thinking skills and mood-related symptoms. Participants will use a de…

This study is testing whether a home-based brain stimulation device can help improve mood, anxiety, and apathy in people with Alzheimer's disease. Researchers are enrolling 24 older adults with Alzheimer's and their caregivers to use the device at home for 30-minute sessions. The…

This study is testing special listening exercises to help people with mild brain injuries hear better. Many people struggle to understand speech in noisy places or locate where sounds are coming from after such injuries. Researchers want to see if computer-based hearing training …

This study compares two types of talk therapy to help military personnel with sleep problems after a mild brain injury. Researchers want to see which therapy works better for improving sleep and reducing other lingering symptoms like headaches and memory issues. The study involve…

This study is testing whether a talk therapy for headaches works just as well when delivered by video call as it does in person. It will involve 525 veterans and active-duty service members who have chronic headaches following a brain injury. Researchers will compare video therap…

This study aims to understand how gastric bypass surgery affects the body's insulin production and blood sugar control. Researchers are recruiting people who have had the surgery—some with and some without low blood sugar problems—as well as healthy people who haven't had surgery…

This study aims to better understand how liver cancer affects older adults and how they respond to treatments. Researchers will observe 84 participants with advanced liver cancer, focusing on those aged 65 and older. The goal is to identify treatment patterns and side effects to …

This study aims to understand how adding two specific fatty acids (DHA and ARA) to the diet of very premature infants affects their body's internal processes. Researchers will enroll 328 babies born very early and measure changes in blood fats and other biological markers related…

This study aims to understand how the diabetes drug pioglitazone affects energy production inside liver cells in people with Type 2 diabetes and fatty liver disease (NAFLD or NASH). Researchers will measure chemical processes in the liver before and after 16 weeks of treatment. T…

This early-phase study aims to understand how a common diabetes medication (empagliflozin) affects muscle energy production and heart function in people who have both type 2 diabetes and heart failure. Researchers will measure changes in muscle chemicals and heart performance ove…

This study is testing a special mental training program designed to help soldiers handle stress and stay ready for difficult missions. It will involve 600 soldiers from a specialized Army unit. Researchers will compare this new training, based on Acceptance and Commitment Therapy…

This research center aims to understand and eventually treat chromosome 18 abnormalities by collecting detailed medical information over time. The study will enroll up to 4,000 individuals with these genetic conditions and their families. Researchers will perform various tests an…

This study aims to see if 3D x-rays can help doctors determine when dental implants are ready to be placed after sinus surgery. Researchers will take 3D x-rays right after surgery and again six months later to measure bone changes. The study involves 25 adults who need sinus surg…

This study aims to understand why gastric bypass surgery helps control blood sugar and promotes weight loss. Researchers will measure gut hormones in 80 people, including those who have had the surgery and some who experience low blood sugar afterward. The goal is to learn how th…

This research study aims to understand how middle-aged men and women's muscles recover after a period of not being used. Healthy participants aged 50-65 will have one leg immobilized for a week, followed by a week of rehabilitation exercise. Researchers will measure muscle change…

This study is looking at how well 'smart' medication pumps work when they are connected to a patient's electronic health record in eight adult intensive care units. Researchers will survey and interview nurses, watch them use the pumps in practice, and review past patient records…

This study aims to find new genes linked to rare tumors called pheochromocytomas and paragangliomas, which often run in families. Researchers will analyze genetic and health information from 2,000 participants who have these tumors or related conditions. The goal is to better und…

This study aims to understand how the hormone glucagon controls blood sugar in people who have had weight-loss surgery compared to those who haven't. Researchers will use an experimental drug that blocks glucagon's effects to see how it changes the body's response to meals and su…

This early-stage study aims to understand how two common type 2 diabetes medications, empagliflozin and pioglitazone, interact in the body. Researchers will measure how they affect the body's production of sugar, fat breakdown, and ketones in 64 participants. The goal is to gathe…

This study aims to understand how trauma therapy helps teens with PTSD by looking at brain changes. Researchers will scan the brains of 180 teens before and after each phase of therapy to see which parts of the brain change during treatment. The goal is to learn how therapy works…

This study aims to understand how two common weight-loss surgeries—gastric bypass and sleeve gastrectomy—affect the body's blood sugar control after eating. Researchers will compare 200 participants, including people who have had surgery, those with low blood sugar after surgery,…