The University Of Texas Health Science Center At San Antonio

This early-phase trial tests whether adding two drugs—loncastuximab and roflumilast—to the standard R-CHOP chemotherapy regimen can safely treat people with untreated, high-risk diffuse large B-cell lymphoma (DLBCL). The study enrolls about 10 adults with this aggressive lymphoma…

This study is testing a borate-based bioactive glass fiber matrix, a special dressing that releases minerals to help heal wounds, in people with diabetes who have foot ulcers and a bone infection. Researchers will watch 20 patients to see if the glass helps the wound close comple…

This early-phase study is testing two drugs, rapamycin and everolimus, in 194 healthy adults aged 65 to 90. The goal is to find a safe dose and timing that can reduce a key aging signal in cells to levels seen in younger people. The researchers also want to see if the best dose d…

This study tests whether regular sessions of passive heat therapy (like sitting in a warm room or bath) can improve blood vessel health in people with spinal cord injury. About 48 adults will either receive heat therapy or a placebo for 60 minutes, 4 times a week for 8 weeks, mos…

After a child has their tonsils removed, bleeding can sometimes occur and may require another surgery. This pilot study tests whether a nebulized mist of the drug tranexamic acid (TXA) can stop the bleeding without needing to touch the sore area. Twelve children aged 2 to 17 who …

This trial tests whether removing both the main pancreatic tumor and small spots in the liver or lungs after chemotherapy can help patients. It includes 40 people whose cancer has spread to only a few spots. Everyone gets the same treatment: chemo first, then surgery if the cance…

This study tests Quitxt, a bilingual text and chat program designed to help young Latino adults (ages 18-29) quit smoking. About 1,200 participants will be randomly assigned to receive Quitxt or standard quit-smoking texts. Researchers will check if they've quit at 1, 3, and 6 mo…

This study tests a drug called sacituzumab govitecan in 32 adults whose glioblastoma (a type of brain cancer) has returned after standard treatment. The drug targets a protein called Trop-2 found on tumor cells. The main goal is to see if patients live longer compared to past res…

This phase 3 trial compares two initial drug combinations for people recently diagnosed with type 2 diabetes. One group gets pioglitazone plus tirzepatide (Mounjaro), the other gets metformin plus sitagliptin. The study will track how well each combo lowers blood sugar and how lo…

This study is testing a treatment called IR-TMS, which uses magnetic pulses to target specific brain areas, to see if it can help people with Alcohol Use Disorder drink less. About 150 adults who drink heavily will receive several sessions of this treatment, along with brain scan…

This study looks at whether the diabetes drug pioglitazone can improve how the liver processes energy in people with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Researchers will measure liver mitochondrial function using special tracers before and after 16 weeks…

This study looks at two methods to preserve the jawbone after a tooth is pulled. After extraction, the bone can shrink, so a graft is placed in the socket to maintain bone volume for a future dental implant. Researchers will compare a synthetic calcium apatite material in a colla…

This study tests a combination of two immunotherapy drugs (tremelimumab and durvalumab) in 32 people with advanced liver cancer who also have moderate cirrhosis (Child-Pugh B). The main goal is to see if the treatment is safe and tolerable, and to measure how well it shrinks tumo…

This study tests several affordable oral medications—including semaglutide, empagliflozin, metformin, and pioglitazone—to see if they can reverse prediabetes, promote weight loss, and lower heart disease risk in Hispanic adults. Researchers will monitor blood sugar, body fat, and…

This study tests whether a gel made from enamel proteins can thicken gum tissue around dental implants. Researchers will measure gum thickness in 32 adults who need implant uncovering surgery. The goal is to see if this treatment improves gum health and implant stability.

This early-stage trial tests whether adding avasopasem to standard hormone therapy and a CDK4/6 inhibitor can help women with metastatic hormone receptor-positive breast cancer that has stopped responding to treatment. The study will enroll 35 participants and focus on safety, wh…

This study tests whether cognitive behavioral therapy (CBT) delivered via telemedicine can reduce headache-related disability in 525 veterans and service members with chronic posttraumatic headache after a mild or moderate brain injury. Participants will be randomly assigned to i…

This study is testing whether a natural oil pulling mouthwash (GuruNanda) can whiten teeth better than a standard whitening mouthwash or a placebo. 120 healthy adults will use one of three rinses nightly for a period. Researchers will measure tooth shade and stain levels using sp…

This study tests whether transcranial magnetic stimulation (TMS) can help teens aged 12-20 who still have PTSD symptoms after finishing trauma-focused therapy. About 20 participants will receive 10 TMS sessions over a month. The goal is to see if TMS is safe and acceptable, and t…

This study tests a new treatment for anger and aggression caused by past betrayal during military service. It will include 40 active duty service members and veterans. Participants will complete 14 treatment modules twice a week and fill out surveys before, during, and after the …

This study tests whether doing high-intensity exercise before virtual reality training can improve balance and brain flexibility in people with Parkinson's disease. Sixteen participants will be split into two groups: one does intense exercise plus VR, the other does stretching pl…

This study tests a new exercise method for people with Parkinson's disease. Researchers will see if partially restricting blood flow to the legs during balance-challenging strength exercises can improve symptoms. The study involves 20 participants aged 40 to 85 and focuses on whe…

This study tests a new type of talk therapy for veterans and service members who have both PTSD and a mild or moderate traumatic brain injury. The therapy focuses on relaxation, stress management, and problem solving instead of asking patients to relive their trauma. The goal is …

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This study tests whether a non-invasive device that sends a mild electrical current to the brain (tDCS) can improve mood, reduce apathy, and ease irritability in people with Alzheimer's disease. Participants use the device at home for 30-minute sessions. The study involves 24 adu…

This pilot study tests whether a gentle brain stimulation device (tDCS) used at home can help with cognitive and behavioral symptoms in Huntington's disease. Sixteen adults with early to moderate Huntington's will use the device daily for 30 minutes, alternating between real and …

This study compares two types of talk therapy for insomnia in 160 active-duty military members who have had a mild traumatic brain injury and still have symptoms like trouble sleeping, thinking, or mood issues. One therapy is longer (6 sessions) and the other is shorter (4 sessio…

This early-phase study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. Researchers will compare a single amino acid (valine) with a mix of essential amino acids in 28 adults on …

This study aims to find the best strategies for veterans with PTSD who aren't helped by their first treatment. Researchers will test a flexible version of Cognitive Processing Therapy and text message reminders to encourage homework completion. The goal is to match the right type…

This study tests whether targeted auditory training exercises can improve hearing in people who have had a mild traumatic brain injury (mTBI). Many with mTBI struggle to hear clearly in noisy environments or locate where sounds come from. Researchers will enroll 80 adults aged 18…

This study tests whether low-frequency ultrasound baths can improve muscle strength, thinking skills, and immune health in healthy adults aged 70 and older. Twenty participants will either receive ultrasound baths three times a week for 8 weeks or sit in a bath without ultrasound…

This study tests whether using a microscope during gum surgery leads to better healing than standard dental loupes (magnifying glasses). About 25 adults with gum disease will take part. Researchers will check how well the gums heal and how long the stitching takes.

This study compares two antipsychotic drugs, pimavanserin and quetiapine, to see which one better reduces hallucinations and delusions in people with Parkinson's disease or dementia with Lewy bodies. About 94 participants will be randomly assigned to one of the two medications, a…

This study tests whether a one-time injection of a local anesthetic into a nerve bundle in the neck (stellate ganglion block) can improve the effects of a type of talk therapy called prolonged exposure for PTSD. The trial involves 140 current or retired military members with PTSD…

This study looks at how a stellate ganglion block injection affects sleep in U.S. service members and veterans with PTSD who are already receiving talk therapy. About 40 participants will wear an EEG headband for three nights before and three nights after the injection to measure…

This study looks at how well smart pumps that talk to electronic health records work in 8 adult intensive care units. Researchers will interview nurses, review pump data, and run simulations to see if the technology reduces medication errors and is easy to use. About 485 nurses a…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Twenty participants who already have a DBS implant will spend two nights in a sleep lab—one night with the device on and one night with it off. Researchers will measure sleep qu…

This study looks at how the hormone glucagon influences blood sugar in people who have had bariatric surgery and those who haven't. Researchers will use an experimental drug called REMD-477 to block glucagon and measure changes in glucose metabolism. The goal is to better underst…

This early study looks at how two diabetes drugs, empagliflozin and pioglitazone, interact in the body. Researchers want to see if pioglitazone can reduce the ketones (a type of acid) that empagliflozin sometimes produces. The study involves 64 adults with type 2 diabetes and mea…

This study looks at how a ketogenic (high-fat, low-carb) diet affects the area around breast cancer tumors. Twelve postmenopausal women with early-stage breast cancer will follow the diet for 3 weeks before their surgery. Researchers will measure changes in immune cells and keton…

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study collects tumor samples from 150 lung cancer patients to grow miniature versions called organoids in the lab. Researchers will test how these organoids respond to chemotherapy and targeted drugs, and compare that to how the patient's actual tumor responds. They will als…

This study looks at how tirzepatide, a weight-loss drug, affects muscle mass and strength in adults aged 50 and older with obesity. Researchers want to know if losing weight with this drug also causes harmful muscle loss that could lead to frailty. Twenty participants will take t…

This study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use energy from ketones. Researchers want to see if these changes can improve exercise ability and daily function in 30 adults with type 2 diabetes and heart failure. Participan…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…

This early-phase study is testing whether a drink containing ketones can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days while researchers measure heart efficiency wi…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which brain networks are involved. The goal is to learn how therapy works in the brain, which cou…

This study is observing 84 adults with advanced liver cancer that cannot be removed by surgery. Researchers want to learn how the disease progresses, what treatments are used, and what side effects occur, especially in patients 65 and older. Participants will complete geriatric a…

This study is gathering medical and educational information from up to 4,000 people with chromosome 18 abnormalities and their families. The goal is to better understand these rare conditions and provide better resources and care. Participants must be at least one year old and in…

This study looks at whether a special training program called Acceptance and Commitment Training (ACT) can help soldiers handle stress better and stay ready for tough missions. About 600 soldiers from the 3rd Security Force Assistance Brigade will take part. Researchers will comp…

This study is testing whether a 3D X-ray (CBCT) can help dentists see if the jawbone has healed enough for a dental implant after a sinus lift procedure. Twenty-five adults who need a sinus lift for an implant will get a 3D scan right after surgery and again 6 months later. The g…

This study looks at the genes of people with rare nervous system tumors called pheochromocytoma and paraganglioma. Researchers want to find the genetic changes that cause these tumors and how they affect health. Up to 2,000 patients and their family members will provide DNA sampl…

This study looks at how giving DHA and ARA supplements to very premature babies (born at 25 to 29 weeks) affects their metabolism and inflammation. Researchers will measure fatty acid levels and other biomarkers in blood. The goal is to understand how these nutrients work in the …

This study looks at how gastric bypass and sleeve gastrectomy affect blood sugar control after eating. Researchers will give two drugs—Exendin-(9-39) and atropine—to understand the roles of hormones and nerves. The goal is to learn why some patients develop low blood sugar after …

This study looks at how gastric bypass surgery affects insulin and blood sugar control, focusing on gut hormones and nerve signals. Researchers will compare three groups: people who had the surgery and now have severe low blood sugar, those who had the surgery without symptoms, a…

This study looks at how a hormone called GLP-1 helps control blood sugar and weight loss after gastric bypass surgery. Researchers will give a drug that blocks GLP-1 to 80 people, including those who had surgery and healthy controls, to measure its effects. The goal is to underst…