Scientists probe why gastric bypass causes dangerous blood sugar drops

NCT ID NCT00992901

Recruiting now Knowledge-focused Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at how gastric bypass surgery affects insulin and blood sugar control, focusing on gut hormones and nerve signals. Researchers will compare three groups: people who had the surgery and now have severe low blood sugar, those who had the surgery without symptoms, and healthy volunteers without surgery. Participants receive short-acting drugs to measure how their bodies respond, helping explain why some develop life-threatening hypoglycemia years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exendin-(9-39), Atropine, GLP-1 and GIP
What this could lead to: If successful, this could clarify why some people develop dangerous low blood sugar after gastric bypass, pointing toward better prevention or treatment.
What could go wrong: This is an early-phase observational study, not testing a new treatment. Results may not lead to direct therapies, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperinsulinemic hypoglycemia hypoglycemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOGLYCEMIA POST BARIATRICSURGERY

Contacts and locations

Locations

South Texas Veterans Health Care System
RECRUITING

San Antonio, Texas, 78229, United States
Texas Diabetes Institute - University Health System
RECRUITING

San Antonio, Texas, 78207, United States

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