Which antipsychotic works best for lewy body psychosis? new trial aims to find out
NCT ID NCT05590637
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two antipsychotic drugs, pimavanserin and quetiapine, to see which one better reduces hallucinations and delusions in people with Parkinson's disease or dementia with Lewy bodies. About 94 participants will be randomly assigned to one of the two medications, and their symptoms will be tracked using a standard questionnaire. The goal is to provide real-world guidance for doctors choosing between these treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pimavanserin (Nuplazid) and quetiapine (Seroquel)
What this could lead to
If it works, this could help doctors choose the best antipsychotic for managing hallucinations and delusions in people with Lewy body disease.
What could go wrong
This is a small, early-phase trial with only 94 participants, so results may not apply to everyone. Both drugs have known side effects, and the study compares existing treatments, not a new breakthrough.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UT Health Science Center - San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Health System
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••