The University Of Texas Health Science Center At San Antonio

This early-phase trial will test the safety and blood levels of an investigational drug called MCAM in 24 healthy adults. Participants will receive a single dose of MCAM or a placebo and be monitored for 8 days. The goal is to find the highest safe dose for future studies on opio…

This study looks at whether adding pioglitazone (a type 2 diabetes drug) to dapagliflozin (an SGLT2 inhibitor) can reduce the liver's glucose production, fat breakdown, and ketone production in people with type 1 diabetes. These effects from dapagliflozin can raise the risk of ke…

This study tests whether taking memantine (a memory drug) plus raloxifene (a bone drug) can help prevent memory loss in adults receiving radiation for brain tumors. About 108 participants will be followed with MRI scans to see if their brain's memory center stays healthier. The g…

This study tests a smartphone app called KIOS designed to help people recovering from opioid addiction manage their health. Researchers will track how well participants stay in treatment over one year and who benefits most from the app. About 134 adults who recently started bupre…

This study tests whether a medicated mist (nebulized tranexamic acid) can safely stop bleeding in children after tonsil removal. About 30 kids aged 2 to 17 who experience bleeding will receive the mist instead of going back to the operating room. The goal is to see if this approa…

This study tests a 6-week exercise program called SwallowFit designed to improve swallowing fitness in people with Parkinson's disease. Researchers will compare the exercise group to those receiving standard care. The goal is to see if the exercises lead to safer swallowing and b…

This early-stage study tests whether bupropion, a medicine used for smoking cessation and depression, can reduce severe tiredness in people with end-stage kidney disease on dialysis. Sixteen participants will take bupropion three times a week for 8 weeks and report their fatigue …

This study tests whether two types of amino acids (protein building blocks) can safely improve muscle mass and strength in 20 adults aged 45-75 with advanced chronic kidney disease and sarcopenia (muscle loss). Participants will take the supplements for 6 weeks while researchers …

This study will test a program called Functional Restoration (FORT) to help active-duty military personnel manage chronic musculoskeletal pain. The program will be rolled out at six military treatment facilities, and researchers will see how well it works and what helps or hinder…

This study tests whether a single 30-60 minute Crisis Response Planning (CRP) session can reduce suicide risk in 120 active-duty military personnel who have had a mild traumatic brain injury (mTBI). Participants will be randomly assigned to CRP or usual care, and researchers will…

This study tests a web-based program called SCIPI that provides men with localized prostate cancer easy-to-understand information, communication tools, and social support. About 200 newly diagnosed patients will be randomly assigned to use SCIPI or receive usual care. Researchers…

This early-stage study tests whether a device that gently stimulates a nerve in the ear is safe and practical for people with moderate to severe traumatic brain injury. Sixteen adults will receive either real or sham stimulation while in the hospital. The main goal is to see if t…

This study aims to discover rare genetic changes that make people more likely to develop cancer. Researchers will collect blood, saliva, and tumor samples from 100 participants who have had multiple cancers or have a strong family history of cancer, along with their relatives. By…