Massive trial aims to settle debate: which common surgery drug saves kidneys?

NCT ID NCT06802224

Recruiting now Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two standard blood pressure medications, norepinephrine and phenylephrine, given during major non-cardiac surgery to prevent acute kidney injury. About 18,000 adults having surgery lasting at least two hours will be included. Hospitals will alternate which drug they use each month, and researchers will track kidney and heart outcomes using routine medical data.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine and phenylephrine
What this could lead to: If this trial succeeds, it could identify which standard blood pressure drug is better at preventing kidney and heart complications after major surgery.
What could go wrong: This is a large pragmatic trial, but it compares two already-approved drugs, so the difference may be small. Results may not apply to all surgery types or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY (AKI) ANESTHESIA HYPOTENSION DURING SURGERY MYOCARDIAL INJURY AFTER NONCARDIAC SURGERY (MINS) NONCARDIAC SURGERY SURGERY WITH GENERAL ANESTHESIA VASOPRESSOR

Contacts and locations

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Henry Ford Health
RECRUITING

Detroit, Michigan, 48202, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Maryland
RECRUITING

College Park, Maryland, 20742, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Wake Forest University School of Medicine
RECRUITING

Winston-Salem, North Carolina, 27101, United States

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