SURGICAL SITE INFECTION

This study compares giving antibiotics only during heart surgery versus continuing them for 24 or 48 hours after. The goal is to see if shorter use prevents surgical site infections just as well, while reducing side effects and costs. About 9,180 adults having heart surgery throu…

This study compares a new suture coated with chlorhexidine (Novosyn CHD) to a standard uncoated suture for closing wounds after abdominal surgery. About 3,000 adults having emergency or planned laparotomy or laparoscopic surgery will take part. The goal is to see if the coated su…

This study compares two liquids—chlorhexidine and saline—used to flush the surgical area during colorectal cancer surgery. The goal is to see which one better prevents surgical site infections and other complications within 30 days after surgery. About 532 adults aged 18-85 with …

This study tests a special vacuum dressing (negative pressure wound therapy) on the incision after emergency belly surgery. It aims to see if it reduces wound complications like infection or reopening compared to a regular bandage. About 720 adults with a midline incision longer …

This study tests whether rinsing the surgical wound and abdominal cavity with a diluted iodine solution can prevent infections better than the standard saltwater rinse. About 1,100 adults aged 18–80 having emergency abdominal surgery with contaminated wounds will take part. The g…

This study tests if giving antibiotics through a vein or using stitches coated with antimicrobial medicine can prevent surgical site infections in children having open groin surgery for hernias or hydroceles. About 174 children will be randomly assigned to receive one of these tr…

This study tests if giving an extra dose of the antibiotic gentamicin directly into the surgical wound during a planned C-section can lower the chance of infection. About 100 women having elective C-sections will either get the extra antibiotic or standard care alone. Researchers…

This study tests a new, gentle treatment called cold atmospheric plasma (CAP) for wounds where tubes enter the body in patients on life support. These wounds often heal slowly and get infected. The study will compare standard wound care alone to standard care plus CAP in 65 adult…

This study looks at whether showering with surgical drains in place after breast reduction or tummy tuck surgery increases the chance of infection or other complications. About 100 adults will be randomly assigned to either shower or not shower while they have drains. The goal is…