SURGICAL SITE INFECTION

This trial compares two ways to clean the wound during spinal instrumentation surgery to prevent surgical site infections. One method uses Irrisept, a chlorhexidine-based antiseptic rinse, while the other uses a vancomycin-saline wash, sometimes with added vancomycin powder. The …

This trial tests whether using an antiseptic body wash and a nasal antibiotic ointment for 30 days after colon or small bowel surgery can prevent surgical site infections. About 2,700 adults who had open abdominal surgery will be randomly assigned to receive either the antiseptic…

This study tests if a special vacuum dressing (negative pressure wound therapy) can reduce wound problems like infection or reopening after emergency belly surgery. About 720 adults with a large midline incision will be randomly assigned to get either the vacuum dressing or a reg…

This trial tests whether adding Steri-Strips (adhesive strips) to standard wound closure after a cesarean section reduces complications like infection, fluid buildup, or wound reopening. About 610 women having a C-section will be randomly assigned to receive either standard closu…

This study compares rinsing the surgical area with chlorhexidine (an antiseptic) versus saline (salt water) during colorectal cancer surgery. The goal is to see if chlorhexidine reduces surgical site infections and other complications within 30 days. About 532 adults with resecta…

This study compares giving antibiotics only during heart surgery versus continuing for 24 or 48 hours afterward, to see if shorter use is just as good at preventing surgical site infections. Over 9,000 adults having heart surgery through a breastbone incision will take part. The …

This study compares two types of stitches used to close wounds after abdominal surgery. One stitch has a special coating that may help prevent bacteria from growing, while the other is a standard stitch. About 3,000 adults having emergency or planned abdominal surgery will take p…

This study is testing whether washing the wound and belly cavity with a diluted iodine solution during emergency abdominal surgery can reduce surgical site infections compared to using normal saline. About 1100 adults aged 18 to 80 having certain types of emergency surgery will t…

This pilot study is testing whether giving a single injection of the antibiotic gentamicin into the surgical wound during a planned C-section can reduce the risk of infection afterward. Researchers will compare 100 women who receive this extra local antibiotic plus standard IV an…

This trial tests whether giving an antibiotic before surgery or using stitches coated with an antimicrobial agent can prevent wound infections in children having open groin surgery for hernias or hydroceles. About 174 children will be randomly assigned to one of three groups: ant…

This study tests a new, gentle treatment called cold atmospheric plasma (CAP) for wounds where tubes enter the body in patients on life support. These wounds often get infected and heal slowly. The study will compare standard wound care alone to standard care plus CAP to see if C…

This study looks at whether showering after surgery while drains are still in place raises the risk of infection or other complications. It will include 100 people having breast reductions or tummy tucks at one medical center. Half will be told they can shower, and half will be t…