SURGICAL SITE INFECTION

This study compares giving 80% oxygen versus 33% oxygen during liver or gallbladder surgery to see if higher oxygen levels reduce surgical site infections. About 146 adults having planned abdominal surgery lasting over two hours will take part. Researchers will track infections f…

This study tested two different ways of stitching the belly wall closed after colorectal cancer surgery to see which one better prevents the wound from bursting open. Forty adults having open surgery were randomly assigned to either an interrupted 'figure-of-X' stitch or a contin…

This study tested a special collagen mesh for hernia repair in 30 patients who were at high risk for complications, such as those with diabetes or infections. The mesh is designed to be absorbed by the body and help tissue heal naturally, avoiding problems linked to permanent syn…

This study compared two ways to close skin after colorectal cancer surgery: a tissue adhesive (skin bond) and traditional skin stapling. Researchers looked at wound infection rates within 30 days, pain, and cost in 304 patients. The goal was to see if skin bond leads to fewer inf…

This study tested a checklist to prevent MRSA surgical site infections in over 23,000 veterans undergoing joint replacement or heart surgery. The checklist included using antibiotic ointment and antiseptic baths before surgery, plus antibiotics during surgery. Researchers measure…

This study tested whether washing surgical incisions with an antiseptic (povidone-iodine) or salt water before closing them can prevent infections. Over 2,700 adults having abdominal or groin surgery were randomly assigned to one of three groups: irrigation with povidone-iodine, …

This study tested whether placing a mesh (a supportive screen) during stoma reversal surgery could prevent hernias better than standard closure. 62 patients who had a temporary stoma took part. The researchers measured hernia rates, infections, pain, and hospital stay length.

This study looked at 50 adults who had emergency surgery for a belly infection (peritonitis). It compared a special vacuum dressing (NPWT) with standard wound closure to see which better prevents surgical site infections. The goal was to find a way to help wounds heal faster and …

This study tested whether a special vacuum dressing (negative pressure wound therapy) helps wounds heal better after stoma reversal surgery compared to letting them heal naturally. 72 adults were randomly assigned to one of the two methods. Researchers checked for infection and s…

This study tested a special silver-coated metal plate (LOQTEQ) used to fix broken ankle bones. The goal was to see if it is safe and reduces infections compared to standard uncoated plates. 203 adults with distal fibula fractures took part. Researchers tracked side effects and in…

This large Phase 3 trial tested a new antibiotic gel called D-PLEX, which is placed into the surgical wound during abdominal surgery to slowly release the antibiotic doxycycline over time. The goal was to see if it could prevent surgical site infections better than standard care …

This study tested whether an artificial intelligence-based educational guide could help prevent surgical site infections in women who had a cesarean section. 300 women were split into two groups: one received standard care, and the other also got the AI guide with daily check-ins…

This study tested two different skin cleansers used before cesarean sections to see which one better prevents wound infections. About 1,400 women having C-sections at one hospital were randomly assigned to get either a plain chlorhexidine solution or one mixed with alcohol. Resea…

This study tested whether adding a benzoyl peroxide gel before surgery to the usual iodine cleaning could lower the chance of infection from Cutibacterium acnes bacteria during shoulder surgery. 156 adults scheduled for shoulder surgery were split into three groups: standard iodi…

This study looked at whether giving antibiotics for a shorter time before wisdom tooth removal can still prevent infections. 70 healthy adults having both lower wisdom teeth taken out received either a single dose or multiple doses of IV ampicillin. The main goal was to see how m…

This study looked at whether treating patients who carry Staphylococcus aureus in their nose before knee or hip replacement surgery can reduce surgical site infections. About 90 adults who tested positive for the bacteria and were scheduled for joint replacement took part. The ma…

This study looked at 343 adults with infections in their artificial hip or knee joints. It compared two common surgeries: one-stage (removing and replacing the joint in one operation) and two-stage (removing the joint, treating the infection, then replacing it later). The main go…

This completed study tested a software platform called OR PathTrac that monitors bacteria in operating rooms. The goal was to see if giving hospitals feedback on where germs spread could help reduce surgical site infections. Over 800 adults having surgery took part. The study foc…