New gel could slash infection risk after abdominal surgery

NCT ID NCT04411199

Completed Prevention Sponsor: PolyPid Ltd. Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study tests whether a gel called D-PLEX, which slowly releases the antibiotic doxycycline, can prevent surgical site infections in people undergoing colorectal or abdominal surgery. About 975 participants will receive either D-PLEX plus standard care or standard care alone. The main goal is to see if D-PLEX reduces the number of infections within 30 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: D-PLEX (extended-release doxycycline)
What this could lead to: If effective, D-PLEX could reduce the risk of serious wound infections after abdominal surgery, potentially improving recovery and reducing hospital stays.
What could go wrong: This is a phase 3 trial, but results may not confirm benefit. Risks include side effects from doxycycline or no reduction in infection rates compared to standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABDOMINAL SURGERY COLON SURGERY POST-OP INFECTION SURGICAL SITE INFECTION

Contacts and locations

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Locations

Assaf Harofeh Medical Center

Ẕerifin, 70300, Israel
Augusta Univeristy

Augusta, Georgia, 30912, United States
Bajai Szent Rokus Korhaz, Sebeszeti Osztaly

Baja, 6500, Hungary
Baylor University Medical Center

Dallas, Texas, 75246, United States
Bnai Zion Medical Center

Haifa, 3339419, Israel
Bugát Pál Kórház, Gasztroenterológia - Sebészet

Gyöngyös, 3200, Hungary
Bács-Kiskun Megyei Kórház

Kecskemét, 6000, Hungary
Cantonal Hospital Zenica

Zenica, 72000, Bosnia and Herzegovina
Carmel Medical Center

Haifa, 3436212, Israel
Centro Clinico Academico de Braga Associação - Hospital de Braga

Braga, 4710-243, Portugal
Centrum Medyczne Med-Gastr

Lodz, 91-034, Poland
Fejer-County Saint George University Teaching Hospital, Department of Surgery

Székesfehérvár, 8000, Hungary
First Surgical Clinic

Belgrade, 11000, Serbia
Galilee Medical Center

Nahariya, 2210001, Israel
General Hospital Sremska Mitrovica

Sremska Mitrovica, 22000, Serbia
Health Center Valjevo

Valjevo, 14000, Serbia
Heves Varmegyei Markhot Ferenc Oktatokorhaz es Rendelointezet Sebeszeti es Ersebeszeti osztaly

Eger, 3300, Hungary
IMSP Clinical republican Hospital "Timofei Mosneaga"

Chisinau, MD2025, Moldova
IMSP Institutul de Medicina Urgenta

Chisinau, MD2004, Moldova
IMSP Institutul of Oncologic

Chisinau, MD2025, Moldova
IMSP Spitalul Clinic Municipal "Gheorghe Paladi"

Chisinau, MD2038, Moldova
IMSP Spitalul Clinic Municipal "Sfanta Treime"

Chisinau, MD2068, Moldova
IMSP Spitalul Clinic Republican "Timofei Mosneaga"

Chisinau, MD2025, Moldova
Kaplan Medical Center

Rehovot, 7661041, Israel
LLC American Hospital Network

Tbilisi, 0102, Georgia
LTD "Israeli - Georgian Medical Research Clinic Healthycore"

Tbilisi, 0112, Georgia
LTD Multiprofile Clinic Consillium Medulla

Tbilisi, 0186, Georgia
LTD New Hospitals

Tbilisi, 0114, Georgia
Mures County Clinical Hospital

Târgu Mureş, 540103, Romania
Ochsner Medical Center

New Orleans, Louisiana, 70121, United States
Oncology Institute of Vojvodina

Kamenitz, 21204, Serbia
Our Lady of Lourdes Hospital

Drogheda, A92 VW28, Ireland
PHI Clinical Hospital - Shtip

Skopje, 2000, North Macedonia
PHI General Hospital "Borka Taleski" Prilep

Prilep, 7500, North Macedonia
PHI General Hospital - Strumica

Strumica, 2400, North Macedonia
PHI University Clinic for Surgical Diseases "st.Naum Ohridski - Skopje"

Skopje, 1000, North Macedonia
PHI University Clinic for digestive Surgery

Skopje, 1000, North Macedonia
Penn State Health Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Pest Megyei Flór Ferenc Kórház Sebészeti Osztály

Kistarcsa, 2143, Hungary
Sf. Constantin Hospital

Brasov, 500388, Romania
Shaare Zedek Medical Center

Jerusalem, 9372212, Israel
Sheba Medical Center

Ramat Gan, 5262000, Israel
Soroka Medical Center

Beersheba, 8457108, Israel
Spitalul Clinic JudeIean de Urgenta "Pius Brinzeu", Sectia Chirurgie Generala II

Timișoara, 300723, Romania
Spitalul Clinic Judetean de Urgenta Craiova, Sectia Cbirurgie Generala II

Craiova, 200642, Romania
Spitalul Clinic Judetean de Urgenta Craiova, Sectia Chirurgie Generala III

Craiova, 200642, Romania
Szabolcs-Szatmar-Bereg Varmegyei Korhazak es Egyetemi Oktatokorhaz, Josa Andras Oktatokorhaz, Sebeszeti Osztaly

Nyíregyháza, 4400, Hungary
Szpital Powiatowy im. Marii Skłodowskiej - Curie w Ostrowie Mazowieckiej SPZZOZ

Ostrów Mazowiecka, 07-300, Poland
UCC Nis

Niš, 18000, Serbia
Unidade Local de Saúde da Região de Aveiro E. P. E.

Aveiro, 3810-164, Portugal
Unidade de Saúde Local da Guarda

Guarda, 6300-749, Portugal
University Clinical Center Tuzla

Tuzla, 75000, Bosnia and Herzegovina
University Clinical Centre of the Republic of Srpska

Banja Luka, 78000, Bosnia and Herzegovina
University Hospital Erlangen

Erlangen, 91054, Germany
University of Muenster

Münster, 48149, Germany
University of Szeged, Faculty of Medicine, Dep.of Surgery

Szeged, 6725, Hungary
Uzsoki Utcai Kórház, Sebészeti Osztály

Budapest, 1145, Hungary
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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