SURGICAL SITE INFECTION

This phase 3 trial tests whether adding a local injection of the antibiotic tobramycin to standard IV antibiotics can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because the wound may not get enough blood flow for IV antibiotics…

This study tests whether a bioelectric wound dressing can reduce infections after colon surgery better than the usual antiseptic skin prep. About 20 adults having elective colon surgery will be enrolled. Researchers will measure bacteria levels in skin samples to compare the two …

This study tests whether placing vancomycin powder directly into the wound during spine surgery can prevent infections in high-risk patients, such as those with spinal deformities or tumors. Half of the 76 adult participants will receive the powder, while the other half will not.…

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or sicker patients and may be caused by inflammation harming the brain. The trial includes 82…

This study tests whether a single dose of oral antibiotic (cephalexin or clindamycin) given before certain skin surgeries can prevent surgical site infections. About 574 adults having skin flaps, grafts, or lower-leg procedures will be randomly assigned to receive either the anti…

This study tests whether putting povidone iodine ointment inside the nose before surgery can lower the risk of surgical site infections, especially from staph bacteria, in people having surgery for severe leg, ankle, or foot fractures. About 2000 adults will receive the nose trea…

This study is observing 209 adults undergoing planned abdominal surgery to understand how bacteria might travel from the gut to cause surgical site infections. Researchers collect samples (skin, rectal, blood, and tissue biopsies) during surgery and use DNA sequencing to track ba…

This study collects blood, urine, skin, and stool samples from over 1,200 surgery patients to see if changes in the body's chemistry can predict surgical site infections. The goal is to find a biological test that helps personalize surgical care. No treatment is being tested—only…

This study looks at how the bacteria in your gut change during abdominal surgery and whether those changes can lead to infections at the surgery site. Researchers will collect samples from 120 adults having planned abdominal surgery to track these bacteria. The goal is to better …

This study is looking at how certain white blood cells (neutrophils) behave in patients having spine or abdominal surgery. The goal is to see if differences in these cells can help explain why some patients get infections after surgery. Researchers will compare the immune cell pr…