SURGICAL SITE INFECTION

This study tests whether giving tranexamic acid before major gastrointestinal surgery can lower the chance of delirium (sudden confusion) after the operation. Delirium is common in older or frail patients and may be caused by inflammation harming the brain. The trial involves 826…

This study tests whether placing vancomycin antibiotic powder directly into the surgical wound during open back surgery can prevent infections in high-risk patients, such as those with spinal deformities or tumors. About 76 adults will be randomly assigned to receive either the s…

This study tests whether a bioelectric wound dressing can reduce infections after colon surgery better than the usual chlorhexidine skin prep. About 20 adults having elective colon surgery will be enrolled. Researchers will measure bacteria levels in skin samples to see if the ne…

This study tests whether applying povidone iodine (a germ-killing solution) inside the nose can reduce the risk of surgical site infections, especially those caused by staph bacteria, in patients having surgery for severe leg, ankle, or foot fractures. About 2000 adults are takin…

This study looks at whether taking one dose of an antibiotic before certain skin surgeries can lower the chance of getting an infection. About 574 adults having surgery on their nose, ear, or lower leg will be randomly given either a placebo or an antibiotic pill. They will be ch…

This study looks at how bacteria from the gut might travel to other parts of the body during abdominal surgery and cause wound infections. About 209 adults having planned abdominal surgery will provide skin, gut, blood, and tissue samples. Researchers will use DNA sequencing to t…

This study watches 120 adults having planned abdominal surgery to see how their gut bacteria change during the operation. Researchers collect samples from the gut, blood, and lymph nodes to check if these bacteria move to other parts of the body and cause surgical site infections…

This study tests whether a special 'figure-of-X' stitching pattern is better than the usual continuous stitch for closing the abdominal wall after colorectal surgery. The goal is to see if it reduces the chance of the wound bursting open, a serious complication. About 40 adults h…

This study aims to find out if changes in the body's chemistry after surgery can predict complications, especially surgical site infections. Researchers will analyze blood, urine, and stool samples from over 1200 surgery patients. The goal is to develop a biological test that hel…

This study looks at how certain immune cells (neutrophils) work in patients having planned surgery. The goal is to see if differences in these cells can help predict or explain surgical site infections. About 220 adults will take part, and the research focuses on understanding, n…