Which surgery works best for infected hip or knee replacements?

NCT ID NCT02734134

Completed Knowledge-focused Sponsor: OrthoCarolina Research Institute, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 343 adults with infections in their artificial hip or knee joints. It compared two common surgeries: one-stage (removing and replacing the joint in one operation) and two-stage (removing the joint, treating the infection, then replacing it later). The main goal was to see which approach better prevents the infection from coming back within a year.

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Conditions

The condition(s) this trial relates to.

periprosthetic joint infection Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SURGICAL SITE INFECTION

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States
Hospital for Special Surgery

New York, New York, 10021, United States
Midwest Orthopaedics at Rush University Medical Center

Chicago, Illinois, 60612, United States
OrthoCarolina Research Institue

Charlotte, North Carolina, 28207, United States
Rothman Institute at Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States

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Other studies related to the condition(s) this trial covers.