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Can hospitals safely cut unnecessary antibiotics after Kids' surgeries?

NCT ID NCT04366440

Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study compares two strategies to reduce unnecessary antibiotic use after low-risk surgeries in children. One approach involves changing standard order sets to remove automatic post-operative antibiotics. The other adds extra training and support for hospital staff to help them adopt these changes. The goal is to see which method works better at cutting antibiotic use without increasing surgical site infections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could establish a safe, effective way to reduce unnecessary antibiotic use in children after low-risk surgeries, helping fight antibiotic resistance.
What could go wrong
The study focuses on changing hospital practices, not a new drug or treatment. Success depends on whether hospitals adopt and stick with the changes, and results may vary across different settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

18,267 people

The number who actually took part.

Started

Nov 2020

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

0 days to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Surgeries performed at the Children's Hospitals included in the study and are collected by NSQIP-P. 2. Clean and clean-contaminated surgical procedures within the following specialties that are included in NSQIP-P: General Surgery, Neurosurgery, Orthopedics, Otolaryngology, Plastic Surgery, Otolaryngology, and Urology Exclusion Criteria: 1\. Children undergoing clean or clean-contaminated procedures that are not collected by NSQIP-P data abstractors.

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgical site infection

Contacts and locations

Locations

  • Baylor College of Medicine / Texas Children's Hospital

    Houston, Texas, 77030, United States

  • Harvard Medical School / Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Johns Hopkins University School of Medicine / Johns Hopkins All Children's Hospital

    St. Petersburg, Florida, 33701, United States

  • The Ohio State University College of Medicine / Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • University of Michigan / CS Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • University of Missouri - Kansas City / The Children's Mercy Hospital

    Kansas City, Missouri, 64108, United States

  • University of Utah / Primary Children's Hospital

    Salt Lake City, Utah, 84108, United States

  • University of Washington / Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • Vanderbilt University / Monroe Carell Jr. Children's Hospital at Vanderbilt

    Nashville, Tennessee, 37232, United States

  • Washington University in St. Louis / St. Louis Children's Hospital

    St Louis, Missouri, 63110, United States

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