Heart surgery antibiotic duration under scrutiny: could one dose be enough?
NCT ID NCT05447559
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares giving antibiotics only during heart surgery versus continuing for 24 or 48 hours afterward, to see if shorter use is just as good at preventing surgical site infections. Over 9,000 adults having heart surgery through a breastbone incision will take part. The goal is to reduce unnecessary antibiotic use, which can cause side effects and contribute to antibiotic resistance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cefazolin
What this could lead to
If successful, this could show that a single dose of antibiotic during surgery is enough to prevent infections, reducing side effects and antibiotic resistance.
What could go wrong
This is a large trial, but it's testing a non-inferiority approach—meaning it aims to prove shorter treatment is not worse. There is a risk that shorter treatment may lead to more infections in some patients.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Austin Health
RECRUITINGMelbourne, Victoria, 3084, Australia
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Cabrini Health
RECRUITINGMelbourne, Victoria, 3144, Australia
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Christchurch Hospital
RECRUITINGChristchurch, New Zealand
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Epworth HealthCare
RECRUITINGMelbourne, Victoria, 3121, Australia
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Fiona Stanley Hospital
RECRUITINGPerth, Western Australia, Australia
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Flinders Medical Centre
RECRUITINGAdelaide, South Australia, 5042, Australia
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Flinders Private
RECRUITINGAdelaide, South Australia, 5042, Australia
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Halifax Infirmary
RECRUITINGHalifax, Nova Scotia, Canada
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IJN
RECRUITINGKuala Lumpur, Malaysia
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Princess Alexandra Hospital
RECRUITINGBrisbane, Queensland, 4102, Australia
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, 5000, Australia
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Royal Hobart Hospital
RECRUITINGHobart, Tasmania, 7000, Australia
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Sir Charles Gairdner
NOT_YET_RECRUITINGNedlands, Western Australia, Australia
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St Andrew's War Memorial Hospital
ACTIVE_NOT_RECRUITINGBrisbane, Queensland, Australia
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St George Hospital
ACTIVE_NOT_RECRUITINGSydney, New South Wales, 2217, Australia
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St John of God Subiaco Hospital
RECRUITINGPerth, Western Australia, 6008, Australia
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St Vincent's Hospital
RECRUITINGMelbourne, Australia
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RECRUITINGMelbourne, Victoria, 3004, Australia
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The Prince Charles Hospital
RECRUITINGBrisbane, Queensland, 4032, Australia
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RECRUITINGMelbourne, Victoria, 3050, Australia
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UMMC
NOT_YET_RECRUITINGKuala Lumpur, Malaysia
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UT Southwestern Medical Centre
NOT_YET_RECRUITINGDallas, Texas, 75390, United States
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Victorian Heart Hospital
RECRUITINGMelbourne, Victoria, 3168, Australia
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Waikato Hospital
RECRUITINGHamilton, 3204, New Zealand
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Wakefield Hospital
NOT_YET_RECRUITINGWellington, New Zealand
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Wellington Hospital
RECRUITINGWellington, New Zealand
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Westmead Hospital
RECRUITINGSydney, New South Wales, 2145, Australia
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