Rhode Island Hospital

This trial compares two ways to clean the wound during spinal instrumentation surgery to prevent surgical site infections. One method uses Irrisept, a chlorhexidine-based antiseptic rinse, while the other uses a vancomycin-saline wash, sometimes with added vancomycin powder. The …

This trial tests a family-based, adaptive program for youth aged 8 to 17 who come to the emergency department (ED) with suicidal or self-injurious behavior. The program uses a stepped-care approach, starting with digital psychosocial support and adding text-based communication if…

This study tests whether a drug called treprostinil can help prevent injury to a new kidney during transplant surgery. About 20 adults receiving a deceased donor kidney will get the drug through an IV for two days, starting just before surgery. The goal is to see if it improves b…

This study compares a higher daily dose of buprenorphine (24 mg) to the standard dose (16 mg) to see if it helps people with opioid use disorder stay in treatment longer. About 250 adults who have used fentanyl will be randomly assigned to one of the two doses. The goal is to imp…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This pilot study tests whether taking vitamin A and nicotinamide (a form of vitamin B3) can safely raise blood levels in kidney transplant recipients who have had skin cancer. Thirty participants will take these vitamins or a placebo for six months. The goal is to see if this app…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This study tests whether playing music during a minimally invasive heart valve replacement (TAVR) can lower patient anxiety. 100 adults scheduled for TAVR will either listen to music through headphones or wear headphones without music. Researchers will measure anxiety levels and …

This study tests whether a type of talking therapy called neurobehavioral therapy (NBT) can help people with motor functional neurological disorder (mFND), a condition where the brain has trouble sending the right signals to the body, causing movement problems. The trial will com…

This study tests whether adding dexmedetomidine to a standard nerve block (using ropivacaine) improves pain control after hip replacement surgery. About 120 adults aged 18-80 will receive either the standard block or the block with added dexmedetomidine. The main goal is to see h…

This study tests a small, non-invasive device that stimulates a nerve in the leg to see if it can safely ease Restless Legs Syndrome (RLS) during pregnancy. Fifteen pregnant women between 21 and 26 weeks will use the device for 30-minute sessions over 8 weeks. Researchers will ch…

This study looks at how changing sleep time affects the immune system and breathing in urban children with asthma. Researchers will ask some children to go to bed 90 minutes later for a week, while others keep their usual bedtime. They aim to understand if short sleep worsens ast…