Could cannabis compounds soothe dementia agitation? new trial investigates
NCT ID NCT05644262
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether an oral oil containing THC and CBD can reduce agitation in people with dementia who are eligible for hospice care. About 120 participants will receive either the active drug or a placebo for 12 weeks. The main goal is to see if agitation scores improve after 2 weeks of treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
oral combination of THC and CBD (cannabis-derived compounds)
What this could lead to
If it works, this could offer a new way to ease severe agitation in people with dementia, improving comfort and quality of life.
What could go wrong
This is a mid-stage trial with only 120 participants, so results may not apply to everyone. Side effects from THC/CBD, like dizziness or confusion, are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Case Western Reserve University
Beachwood, Ohio, 44122, United States
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Georgetown University
Washington D.C., District of Columbia, 20007, United States
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Howard University
Washington D.C., District of Columbia, 20059, United States
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Melgar-Caro Medcenter and Community Research (MCMCR)
Miami, Florida, 33145, United States
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Pennington Biomedical Research Center
Baton Rouge, Louisiana, 70808, United States
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Ralph H. Johnson VA Medical Center
Charleston, South Carolina, 29401, United States
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University of Kentucky
Lexington, Kentucky, 40504, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of South Florida
Tampa, Florida, 33612, United States
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Vanderbilt University Medical Center Center for Cognitive Medicine
Nashville, Tennessee, 37212, United States