Could cannabis compounds soothe dementia agitation? new trial investigates

NCT ID NCT05644262

Ongoing Symptom relief Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether an oral oil containing THC and CBD can reduce agitation in people with dementia who are eligible for hospice care. About 120 participants will receive either the active drug or a placebo for 12 weeks. The main goal is to see if agitation scores improve after 2 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral combination of THC and CBD (cannabis-derived compounds)
What this could lead to: If it works, this could offer a new way to ease severe agitation in people with dementia, improving comfort and quality of life.
What could go wrong: This is a mid-stage trial with only 120 participants, so results may not apply to everyone. Side effects from THC/CBD, like dizziness or confusion, are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia Psychomotor Agitation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGITATION DEMENTIA

Contacts and locations

Locations

Case Western Reserve University

Beachwood, Ohio, 44122, United States
Georgetown University

Washington D.C., District of Columbia, 20007, United States
Howard University

Washington D.C., District of Columbia, 20059, United States
Melgar-Caro Medcenter and Community Research (MCMCR)

Miami, Florida, 33145, United States
Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States
Ralph H. Johnson VA Medical Center

Charleston, South Carolina, 29401, United States
University of Kentucky

Lexington, Kentucky, 40504, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of South Florida

Tampa, Florida, 33612, United States
Vanderbilt University Medical Center Center for Cognitive Medicine

Nashville, Tennessee, 37212, United States

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