Could a heart pill slow a hidden dementia?
NCT ID NCT04120766
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether nicorandil, a drug currently used for heart conditions, can help people with a type of dementia called hippocampal sclerosis of aging. This condition is often mistaken for Alzheimer's but has no approved treatments. The trial includes 64 older adults and will measure safety and changes in brain volume over 96 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nicorandil (a drug used for heart conditions, repurposed here)
What this could lead to
If it works, this could point toward a treatment for a common but often overlooked cause of dementia that currently has no therapies.
What could go wrong
This is a small, early-phase trial with only 64 participants. The drug may not slow the disease or could cause side effects. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Kentucky
Lexington, Kentucky, 40504, United States