New study prepares adults with down syndrome for Alzheimer's trials

NCT ID NCT04165109

Recruiting now Knowledge-focused Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study enrolls adults with Down syndrome ages 25-55 into a ready-to-test group. Researchers will track memory, thinking, and brain changes over time to better understand how Alzheimer's disease develops in this population. The goal is to make future clinical trials faster and more effective by having a pre-screened group ready to join.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia Down syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE DEMENTIA DOWN SYNDROME

Contacts and locations

Locations

Advocate Medical Group Adult Down Syndrome Center
NOT_YET_RECRUITING

Park Ridge, Illinois, 60068, United States
Barrow Neurological Institute
RECRUITING

Phoenix, Arizona, 85013, United States
Case Western Reserve University
RECRUITING

Beachwood, Ohio, 44122, United States
Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas
NOT_YET_RECRUITING

Las Vegas, Nevada, 89106, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Institut Jerome Lejeune
RECRUITING

Paris, France, 75018, France
Institute of Memory & Cognition, Tallaght University Hospital
RECRUITING

Dublin, Ireland, 24, Ireland
Linda Crnic Institute for Down Syndrome, University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Massachusetts General Hospital, Co-Enrolling through ABC-DS Only
RECRUITING

Boston, Massachusetts, 02114, United States
New York State Institute for Basic Research in Developmental Disabilities (SIBRDD), Co-Enrolling through ABC-DS Only
RECRUITING

Staten Island, New York, 10314, United States
Oregon Health & Science University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Sant Pau Biomedical Research Institute (IIB Sant Pau)
RECRUITING

Barcelona, 08041, Spain
University of California, Irvine School of Medicine, Co-Enrolling through ABC-DS Only
RECRUITING

Orange, California, 92868, United States
University of Cambridge, Co-Enrolling through ABC-DS Only
RECRUITING

Cambridge, CB2 1TN, United Kingdom
University of Cincinnati
NOT_YET_RECRUITING

Cincinnati, Ohio, 45219, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kentucky, Co-Enrolling through ABC-DS Only
RECRUITING

Lexington, Kentucky, 40504, United States
University of Pittsburgh, Co-Enrolling through ABC-DS Only
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Texas Health San Antonio, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases
RECRUITING

San Antonio, Texas, 78229, United States
University of Wisconsin - Madison, Waisman Center, Co-Enrolling through ABC-DS Only
RECRUITING

Madison, Wisconsin, 53705, United States
Vanderbilt University Medical Center Center for Cognitive Medicine
RECRUITING

Nashville, Tennessee, 37212, United States
Washington University, St. Louis
RECRUITING

St Louis, Missouri, 63108, United States

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