Mysterious moments of clarity in severe dementia under scientific scrutiny

NCT ID NCT05234866

Recruiting now Knowledge-focused Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study investigates paradoxical lucidity—brief, unexpected episodes of mental clarity—in people with end-stage dementia. Researchers will use caregiver diaries and video EEG monitoring to capture and analyze these rare events. The goal is to create a standard definition and measurement scale for paradoxical lucidity, and to identify brain activity patterns that may accompany it. The study involves 520 participants in hospice care with advanced dementia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help define and measure paradoxical lucidity, potentially leading to better understanding and care for people with advanced dementia.
What could go wrong: This is an early observational study, so it may not lead to any treatment. The episodes are rare and brief, and the research is exploratory.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEMENTIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

NYU Langone Health
RECRUITING

New York, New York, 10016, United States

Contact

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