Could an app help shield your brain from Alzheimer's-Linked drugs?
NCT ID NCT04121858
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This study tests whether a smartphone app called Brain Safe can help older adults reduce their use of strong anticholinergic medications, which are linked to a higher risk of Alzheimer's disease. The trial enrolls 700 adults aged 60 and older who currently take such medications. Participants use either the Brain Safe app or a basic medication list app for 12 months, and researchers track changes in medication use and cognitive function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a smartphone app called Brain Safe that provides a medication list, personalized risk calculator, educational content, and a doctor's report
- What this could lead to
- If effective, this app could help older adults lower their exposure to certain medications that are linked to a higher risk of Alzheimer's disease.
- What could go wrong
- This is a behavioral intervention, not a drug, so its impact may be modest. The trial is relatively small and results may not apply to all populations.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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IU Health
Indianapolis, Indiana, 46202, United States
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Indiana University
Indianapolis, Indiana, 46202, United States
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