Lifestyle makeover may stave off dementia in At-Risk seniors

NCT ID NCT06488430

Completed Prevention Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This study looked at how common mild cognitive impairment is among adults aged 50-65 in Kerala, India, and tested a one-month program combining nutrition advice, exercise, brain games, social support, and heart health management. The goal was to see if this approach is practical and acceptable for preventing further cognitive decline. 481 participants were enrolled, and those with mild cognitive impairment received the intervention.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: multidomain intervention package (nutritional advice, physical activity, cognitive stimulation training, social support, and management of vascular risk factors)
What this could lead to: If the intervention is found feasible, it could lead to larger clinical trials testing whether a combination of lifestyle changes can prevent or slow cognitive decline in older adults.
What could go wrong: This is a small, one-month feasibility study, not a large trial. The results may not apply to other populations, and the short duration cannot show long-term benefits or risks.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEMENTIA MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

Believers Church Medical College

Tiruvalla, Kerala, 689 103, India

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