PREECLAMPSIA

This study tests a 9-month program for women who had preeclampsia in their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and lifestyle coaching. Researchers want to see if it lowers blood pressure and helps w…

This study tests a medication called ravulizumab in pregnant people with severe preeclampsia or HELLP syndrome, serious conditions that can harm both mother and baby. The goal is to see if the drug can help control the disease by targeting certain immune system proteins. About 14…

This study tests whether a single IV dose of stem cell exosomes can repair blood vessel damage in 80 women who recently had preeclampsia. Half receive the treatment, half a placebo. The goal is to lower their high risk of future heart disease. Participants are followed for one we…

This study tests whether taking spironolactone for three months after delivery can improve blood pressure and heart health in women who had preeclampsia or gestational hypertension and were overweight before pregnancy. About 204 women will be randomly assigned to receive the drug…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders, such as preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will use CPAP or receive usual care. The goal is to see if treat…

This study tests whether taking low-dose aspirin after pregnancy can repair blood vessel damage in women who had preeclampsia. Preeclampsia increases the risk of heart disease later in life, but no specific treatments exist to prevent this. The trial will measure how well blood v…

This early-stage study tests a single injection of CBP-4888 in 60 pregnant women hospitalized with preterm preeclampsia, a serious condition involving high blood pressure and organ stress. The goal is to find a safe dose and see how the drug affects the body. Participants receive…

This study tests whether taking atorvastatin (a cholesterol-lowering drug) for 3 months after pregnancy can reduce the long-term risk of heart disease in women who had high blood pressure conditions like preeclampsia. 76 women will receive either the drug or a placebo, starting a…

This study tests whether keeping blood pressure below 140/90 mmHg in pregnant women with preeclampsia or gestational hypertension can safely prolong pregnancy. About 132 women between 23 and 35 weeks pregnant will be randomly assigned to either tighter blood pressure control or u…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This study tests whether metformin, a drug used for diabetes, can safely prolong pregnancy in women diagnosed with preterm preeclampsia. Currently, the only way to stop the condition is to deliver the baby early, which can cause health problems for the newborn. The trial will enr…

This study is testing whether measuring how well a pregnant woman's blood vessels work can help predict dangerous conditions like preeclampsia and high blood pressure. Researchers will use two non-invasive devices and blood/urine tests in 400 first-time mothers during early and m…

This study looks at whether a simple lung ultrasound can find fluid overload in pregnant people with severe preeclampsia, a condition that can cause breathing problems after delivery. Researchers will compare ultrasound results with symptoms like shortness of breath and oxygen le…

This study looks at whether three substances in the blood can help doctors diagnose and monitor preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will measure these markers in 120 pregnant women between 20 and 36 weeks. The goal is to find a b…

This large study tests whether a 162 mg daily aspirin dose works better than the standard 81 mg dose to prevent dangerous high blood pressure disorders (like preeclampsia) in pregnant people at risk. Over 10,000 participants will be followed to see which dose reduces complication…

This study looks at whether eating foods rich in natural salicylates (like certain fruits and vegetables) can help prevent preeclampsia, a serious pregnancy complication. Researchers will measure the diet and blood/urine levels of 500 pregnant women, including those with and with…

This study tests whether providing healthy meals, nutrition support, and health coaching to high-risk pregnant women can lower their chances of developing gestational diabetes, high blood pressure, or preeclampsia. About 100 women in early pregnancy will be randomly assigned to e…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can better prevent preeclampsia in pregnant women at high risk. Preeclampsia is a dangerous condition involving high blood pressure and organ damage. The trial will enroll 100…

This study tests whether adding a special type of physical therapy—vagal stimulation with trigger point release—to standard blood pressure medication can better control blood pressure in pregnant women with preeclampsia. Preeclampsia is a serious condition that can harm both moth…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm and skin, and examine placental vessels after delivery. The goal is to s…

This study looks at tiny particles called exosomes released from the placenta that may cause preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these particles in…

This study looks at why women who had preeclampsia during pregnancy are more likely to develop heart disease later in life. Researchers will test how a specific receptor in blood vessels affects function after a high-salt meal. The study involves 40 women (some with past preeclam…

This study aims to find early molecular clues that could predict preeclampsia, a serious pregnancy complication. Researchers will analyze tissue samples from the womb (collected between weeks 9 and 15 of pregnancy) from over 2,000 women. By comparing samples from women who later …

This study looks at whether a blood test measuring certain markers (sFlt-1/PlGF) can help doctors decide when to induce labor in pregnant women with mild preeclampsia at term. The goal is to reduce unnecessary inductions without increasing the risk of severe complications for mot…

This study looks at why pregnant women living at high altitude have higher rates of poor fetal growth and preeclampsia. Researchers will collect tissue samples from 84 women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude). By comparing blood…

This study is testing two new ultrasound techniques to see if they can better detect fetal growth restriction (FGR), a condition where a baby is smaller than expected. Researchers will compare these scans in 60 pregnant women, some with healthy pregnancies and some with FGR. The …

This study looks at pregnant people who are at risk for preeclampsia and are taking aspirin as part of their care. Researchers will collect blood samples up to four times during pregnancy to study tiny particles from the placenta. The goal is to find a set of proteins that can sh…

This study looks at whether a blood gas test can help tell how severe preeclampsia is in pregnant women. Researchers will compare results from 100 women with severe preeclampsia and 100 healthy pregnant women. If the test shows a link, it could become a new tool to predict compli…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure markers of metabolic health, like fatty acids and salicylate levels, in 50 participants. The goal is …

This study aims to understand why low-dose aspirin does not always prevent preeclampsia, a serious pregnancy condition that causes high blood pressure. Researchers will look at genetic, laboratory, and clinical factors in 130 women who had preeclampsia before and took aspirin in …

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers will measure blood vessel stiffness and collect blood samples to understand long-term health risks. No new treatments are given; the goal is to learn how to better …

This study looks at 500 women who recently gave birth—250 with preeclampsia and 250 without—to see if exercise stress tests can spot early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will track heart function and blood markers over a year. The goa…