PREECLAMPSIA

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This study tests whether a mobile health program—combining home blood pressure monitoring with virtual coaching—can help midlife women control high blood pressure after having had a hypertensive disorder of pregnancy (like preeclampsia). About 50 women who had such a pregnancy 10…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether a quick bedside ultrasound can help doctors decide if new mothers with preeclampsia need a diuretic (water pill) to lower their blood pressure. About 96 postpartum patients will be enrolled. The goal is to see if this approach speeds up blood pressure rec…

This study tests two progestin-only birth control pills—drospirenone and norethindrone—to see which one helps control high blood pressure after a pregnancy complicated by preeclampsia. Fifty women will take one of the pills daily for six weeks after leaving the hospital. The goal…

This study looks at whether giving enalapril, a standard blood pressure medicine, to women who had preeclampsia during pregnancy can help control their blood pressure after childbirth. Researchers will enroll 60 postpartum women and randomly assign them to enalapril or usual care…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This study looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Over 15,000 women across Europe and Africa will be randomly assigned to stop or continue aspirin. The goal is to see …

This study tests whether notifying obstetric clinicians when a pregnant patient is at high risk for preeclampsia increases the use of low-dose aspirin, which can help prevent the condition. Researchers will compare clinics that receive these alerts to those that continue usual ca…

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This study tests whether taking 2,000 IU of vitamin D daily during pregnancy can prevent preeclampsia, eclampsia, and HELLP syndrome in about 2,000 pregnant women in Uganda. Half the women will receive vitamin D and half a placebo, and researchers will track outcomes up to six we…

This study tests an injection called topefilgrastim in 100 pregnant women at high risk for preeclampsia, a serious condition that can harm both mother and baby. Participants are split into two dose groups or a control group to see if the drug can lower the chance of developing pr…

This study will test if mindfulness training, with or without a wearable biosensor watch, can help prevent preeclampsia in pregnant women at moderate to high risk. 90 women will be split into three groups: mindfulness plus the watch, mindfulness alone, or standard prenatal care. …

This study looks at whether stretching or aerobic exercises can help women with mild preeclampsia. Sixty first-time pregnant women, ages 20-30, will do one type of exercise for six weeks. Researchers will measure blood pressure and urine protein levels to see which exercise works…

This study looks at whether pregnant women at high risk of preterm birth can safely express breastmilk from week 28 to 34 of pregnancy. Researchers will check if it affects how soon the baby is born, how much milk is available at birth, and whether it helps with breastfeeding. Th…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This study looks at whether allied-health professionals (like pharmacists or nurses) can help recruit and follow women who had preeclampsia during pregnancy. Participants will check their blood pressure at home and work with a research pharmacist for 12 months. The goal is to see…

This study will check if an ultrasound of the internal jugular vein in the neck can predict a sudden drop in blood pressure during spinal anesthesia for C-section in women with preeclampsia. Researchers will measure the vein's collapsibility before surgery and track blood pressur…

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This study will measure a substance called kynurenine in the blood of 204 pregnant women, some with chronic kidney disease and some without. The goal is to see if kynurenine levels are linked to preeclampsia, a serious condition that can harm both mother and baby. Researchers hop…

This study will test whether a formula called fullPIERS can accurately predict serious complications in 50 pregnant women with preeclampsia. The formula uses information like blood pressure, kidney function, and symptoms to estimate risk. If it works well, doctors could use it to…

This study will follow 120 pregnant women with high blood pressure or preeclampsia to see if certain ultrasound scans and blood tests can predict who will develop severe disease. Researchers will measure blood flow in the mother's heart, eyes, and womb, along with lung ultrasound…

This study aims to understand what causes preeclampsia, a serious pregnancy condition. Researchers will measure a protein called sFlt1 in the blood of 500 women, including those with and without the condition. The goal is to find better ways to diagnose and treat this disease in …