Major trial tests if early aspirin stop is safe for Moms-to-Be
NCT ID NCT07665853
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Over 15,000 women across Europe and Africa will be randomly assigned to stop or continue aspirin. The goal is to see if stopping early is just as effective at preventing preterm preeclampsia while reducing side effects like bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
aspirin (acetylsalicylic acid)
What this could lead to
If successful, this could show that stopping aspirin earlier is just as effective for preventing preeclampsia, reducing unnecessary medication and side effects for many pregnant women.
What could go wrong
This is a large phase 3 trial, but it's testing a non-inferiority hypothesis—meaning it aims to prove stopping early is not worse than continuing. There's a risk that stopping earlier might slightly increase preeclampsia cases in certain populations, especially women of African origin.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Brikama District Hospital
Brikama, The Gambia
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Bundung Maternal and Child Health Hospital
Banjul, The Gambia
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Centre Hospitalier Régional de Saint-Louis
Saint-Louis, Senegal
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Clínica Universidad de Navarra
Pamplona, Spain
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Complejo Hospitalario Universitario de A Coruña
A Coruña, Spain
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Consorci Sanitari de Terrassa
Terrassa, Spain
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Dr Shterev Hospital
Sofia, Bulgaria
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Fundación Jiménez Díaz
Madrid, Spain
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Holy Family Hospital
Techiman, Ghana
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Hopital Phillipe Senghor
Dakar, Senegal
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Hospital Arnau de Vilanova de Lleida
Lleida, Spain
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Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, Spain
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Hospital Dr.Josep Trueta
Girona, Girona, 17007, Spain
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Hospital General de Alicante
Alicante, Spain
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Hospital Joan XXIII
Tarragona, Tarragona, 43007, Spain
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Hospital Materno Infantil de Gran Canaria
Las Palmas de Gran Canaria, Spain
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Hospital San Cecilio
Granada, Andalusia, Spain
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Hospital Universitari Dexeus
Barcelona, BARCELONA, 08024, Spain
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Hospital Universitari Mútua Terrassa
Terrassa, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitari Vall d'Hebrón
Barcelona, Spain
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Hospital Universitario Nuestra Señora de Candelaria
Santa Cruz de Tenerife, Spain
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Hospital Universitario Puerta del Mar
Cadiz, Spain
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Hospital Universitario Rey Juan Carlos
Móstoles, Spain
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Hospital Universitario Severo Ochoa
Leganés, Spain
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Hospital Universitario Virgen de las Nieve
Granada, Spain
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Hospital Universitario de Burgos
Burgos, Spain
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Hospital Universitario de Canarias
San Cristóbal de La Laguna, Spain
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Hospital Universitario de Jerez
Jerez de la Frontera, Spain
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Hospital Universitario de Torrejón
Torrejón de Ardoz, Spain
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Hospital de Cruces
Barakaldo, Vizcaya, 48903, Spain
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Hospital de León
León, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
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King's College Hospital
London, United Kingdom
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Medical University of Vienna
Vienna, Austria
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Medway Maritime Hospital
London, United Kingdom
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Saint Patrick Hospital
Ofinso, Ghana
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St Josef Hospital
Vienna, Austria
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