Major trial tests if early aspirin stop is safe for Moms-to-Be

NCT ID NCT07665853

Not yet recruiting Prevention Sponsor: Hospital Universitari Vall d'Hebron Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Over 15,000 women across Europe and Africa will be randomly assigned to stop or continue aspirin. The goal is to see if stopping early is just as effective at preventing preterm preeclampsia while reducing side effects like bleeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aspirin (acetylsalicylic acid)
What this could lead to: If successful, this could show that stopping aspirin earlier is just as effective for preventing preeclampsia, reducing unnecessary medication and side effects for many pregnant women.
What could go wrong: This is a large phase 3 trial, but it's testing a non-inferiority hypothesis—meaning it aims to prove stopping early is not worse than continuing. There's a risk that stopping earlier might slightly increase preeclampsia cases in certain populations, especially women of African origin.

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Conditions

The condition(s) this trial relates to.

preeclampsia prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREECLAMPSIA

Contacts and locations

Locations

Brikama District Hospital

Brikama, The Gambia
Bundung Maternal and Child Health Hospital

Banjul, The Gambia
Centre Hospitalier Régional de Saint-Louis

Saint-Louis, Senegal
Clínica Universidad de Navarra

Pamplona, Spain
Complejo Hospitalario Universitario de A Coruña

A Coruña, Spain
Consorci Sanitari de Terrassa

Terrassa, Spain
Dr Shterev Hospital

Sofia, Bulgaria
Fundación Jiménez Díaz

Madrid, Spain
Holy Family Hospital

Techiman, Ghana
Hopital Phillipe Senghor

Dakar, Senegal
Hospital Arnau de Vilanova de Lleida

Lleida, Spain
Hospital Clínico Universitario Virgen de la Arrixaca

Murcia, Spain
Hospital Dr.Josep Trueta

Girona, Girona, 17007, Spain
Hospital General de Alicante

Alicante, Spain
Hospital Joan XXIII

Tarragona, Tarragona, 43007, Spain
Hospital Materno Infantil de Gran Canaria

Las Palmas de Gran Canaria, Spain
Hospital San Cecilio

Granada, Andalusia, Spain
Hospital Universitari Dexeus

Barcelona, BARCELONA, 08024, Spain
Hospital Universitari Mútua Terrassa

Terrassa, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitari Vall d'Hebrón

Barcelona, Spain
Hospital Universitario Nuestra Señora de Candelaria

Santa Cruz de Tenerife, Spain
Hospital Universitario Puerta del Mar

Cadiz, Spain
Hospital Universitario Rey Juan Carlos

Móstoles, Spain
Hospital Universitario Severo Ochoa

Leganés, Spain
Hospital Universitario Virgen de las Nieve

Granada, Spain
Hospital Universitario de Burgos

Burgos, Spain
Hospital Universitario de Canarias

San Cristóbal de La Laguna, Spain
Hospital Universitario de Jerez

Jerez de la Frontera, Spain
Hospital Universitario de Torrejón

Torrejón de Ardoz, Spain
Hospital de Cruces

Barakaldo, Vizcaya, 48903, Spain
Hospital de León

León, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Spain
King's College Hospital

London, United Kingdom
Medical University of Vienna

Vienna, Austria
Medway Maritime Hospital

London, United Kingdom
Saint Patrick Hospital

Ofinso, Ghana
St Josef Hospital

Vienna, Austria

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