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Could a common diabetes drug help delay preterm birth in preeclampsia?

NCT ID NCT06033131

Recruiting now Disease control Sponsor: Lina Bergman Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether metformin, a diabetes drug, can safely prolong pregnancy in women with preterm preeclampsia. Currently, the only treatment is early delivery, which risks the baby's health. The study will enroll 294 women across Nordic countries, giving them metformin or a placebo from diagnosis until delivery. The goal is to see if metformin can extend gestation, increase birth weight, and reduce time babies need in neonatal care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Metformin (a diabetes drug)
What this could lead to
If it works, this could offer a way to safely prolong pregnancy in preterm preeclampsia, reducing complications from early delivery.
What could go wrong
This is still a trial, and metformin may not effectively delay delivery. Side effects like nausea or diarrhea are possible, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Birth Weight preeclampsia Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREECLAMPSIA

Contacts and locations

Locations

  • Akershus University Hospital

    RECRUITING

    Lørenskog, N-1474, Norway

  • Danderyd Hospital

    RECRUITING

    Stockholm, 182 88, Sweden

  • Falu Lasarett

    RECRUITING

    Falun, 79129, Sweden

  • Helsinki University Hospital

    NOT_YET_RECRUITING

    Helsinki, 00290, Finland

  • Karolinska University Hospital Huddinge

    RECRUITING

    Stockholm, 14157, Sweden

  • Karolinska University Hospital Solna

    RECRUITING

    Stockholm, 17176, Sweden

  • Linköping University Hospital

    RECRUITING

    Linköping, 581 85, Sweden

  • Norra Älvsborgs County Hospital

    RECRUITING

    Trollhättan, 461 74, Sweden

  • Norrland´s University Hospital

    RECRUITING

    Umeå, 901 85, Sweden

  • Oslo University Hospital

    RECRUITING

    Oslo, 0372, Norway

  • Sahlgrenska University Hospital

    RECRUITING

    Gothenburg, 416 85, Sweden

  • Skåne University Hospital

    RECRUITING

    Lund, 221 85, Sweden

  • Skåne University Hospital

    RECRUITING

    Malmö, 205 02, Sweden

  • Södra Älvsborgs Hospital

    RECRUITING

    Borås, 50455, Sweden

  • Tampere University Hospital

    RECRUITING

    Tampere, 33520, Finland

  • Uppsala University Hospital

    RECRUITING

    Uppsala, 75237, Sweden

  • Västmanlands Hospital Västerås

    RECRUITING

    Västerås, 72335, Sweden

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