Daily aspirin may shield hearts after preeclampsia

NCT ID NCT04479072

Recruiting now Disease control Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking a daily low-dose aspirin for six months after childbirth can improve heart function in women who had preeclampsia. Preeclampsia can raise a protein called Activin A, which may harm the heart. The trial will compare aspirin to a placebo in 180 women, measuring heart function and Activin A levels at six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin 81 mg (acetylsalicylic acid)
What this could lead to: If it works, this could point toward a simple, low-cost way to protect heart health in women who have had preeclampsia.
What could go wrong: This is a small, early-phase trial (180 people) testing a biomarker, not a direct health outcome. Aspirin may not improve heart function, and results may not apply to all women.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder hypertensive disorder preeclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREECLAMPSIA POSTPARTUM

Contacts and locations

Locations

University of Chicago Hospital
RECRUITING

Chicago, Illinois, 60637, United States

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