Can a drug fix blood vessels after preeclampsia? early study hints at possibility

NCT ID NCT07345845

Ongoing Knowledge-focused Sponsor: Anna Stanhewicz, PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why women who had preeclampsia may have lasting blood vessel problems and inflammation. Researchers will test a drug called eplerenone on a small patch of skin to see if it improves blood vessel function. The study involves 40 women, some with a history of preeclampsia and some without, to understand the role of a specific receptor in these issues.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eplerenone (a mineralocorticoid receptor blocker) applied locally to the skin
What this could lead to: If successful, this study could reveal a new target for improving blood vessel health in women who had preeclampsia, potentially reducing their future risk of heart disease.
What could go wrong: This is a very early, small study (40 participants) using only local skin application, not a treatment for the whole body. The results may not translate into a practical therapy.

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Conditions

The condition(s) this trial relates to.

preeclampsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREECLAMPSIA PREECLAMPSIA POSTPARTUM

Contacts and locations

Locations

University of Iowa

Iowa City, Iowa, 52242, United States

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