Metformin may stop severe pregnancy sickness before it starts
NCT ID NCT07129473
First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times
Summary
This study tests whether taking metformin-XR (a diabetes drug) daily before pregnancy can lower the risk and severity of Hyperemesis Gravidarum (HG)—extreme nausea and vomiting in pregnancy—in women aged 18-49 who had HG before and are trying to conceive. Participants either take the drug or join a survey-only group. Researchers will track side effects, HG recurrence, pregnancy outcomes, and newborn health.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Morning Sickness & HG Clinic
NOT_YET_RECRUITINGBirmingham, Alabama, 35223, United States
Contact Email: •••••@•••••
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University of Southern California - Keck School of Medicine
RECRUITINGLos Angeles, California, 90033, United States
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