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New registry to track pregnancy and MS: what happens to mothers and babies?

NCT ID NCT03900221

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This registry follows 1,500 women with multiple sclerosis (MS) or related conditions through pregnancy and after childbirth. Researchers will track relapses, use of disease-modifying drugs, and outcomes for both mothers and children. The goal is to better understand how MS and its treatments affect pregnancy, breastfeeding, and long-term health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this registry could provide clearer guidance for women with MS who are pregnant or planning pregnancy, helping doctors make better recommendations about treatments and care.
What could go wrong
This is an observational registry, not a treatment trial, so it won't directly test any new therapy. Results depend on real-world data, which can be incomplete or biased.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2019

Expected to finish

Aug 2036

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women with multiple sclerosis or related neurological syndromes

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All groups of patients eligible to participate to the Observatoire Français de la Sclérose en Plaque (OFSEP), including : * Definite Multiple sclerosis (MS) according to McDonald criteria * Whatever the clinical course (single attack MS, relapsing-remitting MS, secondary progressive MS, primary progressive MS) * Radiologically Isolated Syndromes (RIS) (will be validated by the RIS expert group) * Clinically Isolated Syndromes (CIS) * Neuromyelitis optica (NMO) and NMO spectrum disorders (will be validated by the "Neuro-optico-myélite aiguë de Devic et des syndromes neurologiques apparentés" (NOMADMUS) expert group) * No age limit (patients under the age of 18 might be included, provided informed consent is obtained from the parents) * Ongoing pregnancy: there will be no limit in the gestational age at inclusion. Women can be included at any time before delivery, but the gestational age at inclusion will be recorded and introduced in the analyses whenever pertinent. However, neurologists and patients will be encouraged to start the study as soon as pregnancy is diagnosed. * Able to give informed consent * Able to read and/or understand French Exclusion Criteria: * None

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Conditions

The condition(s) this trial relates to.

Breast Feeding multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica pregnancy disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myelin oligodendrocyte glycoprotein (MOG)-antibody related disorders Neuromyelitis optica spectrum disorder Pregnancy abnormal Sclerosis, multiple

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    48 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cabinet médical Dr C. CORNUT-CHAUVINC

    RECRUITING

    Lyon, 69008, France

  • Cabinet médical Dr L. GUILLOTON

    RECRUITING

    Mornant, 69440, France

  • Cabinet médical Dr Philippe NEUSCHWANDER

    RECRUITING

    Lyon, 69006, France

  • Centre Hospitalier Annecy Genevois

    RECRUITING

    Annecy, 74000, France

  • Centre Hospitalier Mémorial

    RECRUITING

    Saint-Lô, 50009, France

  • Centre Hospitalier Saint Joseph Saint Luc

    RECRUITING

    Lyon, 69007, France

  • Centre Hospitalier d'Avignon

    RECRUITING

    Avignon, 84000, France

  • Centre Hospitalier de Saint-Denis

    RECRUITING

    Saint-Denis, 93200, France

  • Centre Hospitalier de Versailles Hôpital Andre Mignot

    RECRUITING

    Le Chesnay, 78157, France

  • Centre hospitalier Joséphine Baker Gonesse

    RECRUITING

    Gonesse, 95500, France

  • Centre hospitalier Métropole Savoie

    RECRUITING

    Chambéry, 73000, France

  • Ch Epinal

    RECRUITING

    Épinal, 88000, France

  • Chi Poissy Saint Germain En Laye

    RECRUITING

    Poissy, 78303, France

  • Chr La Miletrie

    RECRUITING

    Poitiers, 86021, France

  • Chru de Lille

    RECRUITING

    Lille, 59037, France

  • Chru de Tours Hopital Bretonneau

    RECRUITING

    Tours, 37044, France

  • Chu D'Amiens

    RECRUITING

    Amiens, 80054, France

  • Chu de Grenoble

    RECRUITING

    Grenoble, 38043, France

  • Fondation Rotschild

    RECRUITING

    Paris, 75019, France

  • Hopital Caremeau

    RECRUITING

    Nîmes, 30029, France

  • Hopital Cote de Nacre

    RECRUITING

    Caen, 14033, France

  • Hopital Du Bocage

    RECRUITING

    Dijon, 21079, France

  • Hopital Dupuytren

    RECRUITING

    Limoges, 87042, France

  • Hopital G. Et R. Laennec

    RECRUITING

    Saint-Herblain, 44800, France

  • Hopital Gabriel Montpied

    RECRUITING

    Clermont-Ferrand, 63003, France

  • Hopital Gui de Chauliac

    RECRUITING

    Montpellier, 34295, France

  • Hopital Hautepierre

    RECRUITING

    Strasbourg, 67098, France

  • Hopital Henri Mondor

    RECRUITING

    Créteil, 94010, France

  • Hopital Jean Minjoz

    RECRUITING

    Besançon, 25030, France

  • Hopital Nord

    RECRUITING

    Saint-Priest-en-Jarez, 42277, France

  • Hopital P. Zobda-Quitman

    RECRUITING

    Fort-de-France, 97200, Martinique

  • Hopital Pasteur

    RECRUITING

    Nice, 06001, France

  • Hopital Pellegrin

    RECRUITING

    Bordeaux, 33076, France

  • Hopital Pitie Salpetriere

    RECRUITING

    Paris, 75651, France

  • Hopital Pontchaillou

    RECRUITING

    Rennes, 35033, France

  • Hopital Purpan

    RECRUITING

    Toulouse, 31059, France

  • Hopital Rene Dubos

    RECRUITING

    Pontoise, 95300, France

  • Hopital Timone Adultes

    RECRUITING

    Marseille, 13385, France

  • Hôpital Central

    RECRUITING

    Nancy, 54035, France

  • Hôpital Charles-Nicolle

    RECRUITING

    Rouen, 76000, France

  • Hôpital Foch

    RECRUITING

    Suresnes, 92151, France

  • Hôpital Neurologique Pierre Wertheimer

    RECRUITING

    Bron, 69677, France

  • Hôpital Paris Saint Joseph

    RECRUITING

    Paris, 75014, France

  • Hôpital Raymond Poincaré

    RECRUITING

    Garches, 92380, France

  • Hôpital St Vincent De Paul

    RECRUITING

    Lille, 59020, France

  • Hôpital de Brive

    RECRUITING

    Brive-la-Gaillarde, 19100, France

  • Hôpital national des Quinze-Vingt.

    RECRUITING

    Paris, 75571, France

  • Médipôle Lyon Villeurbanne

    RECRUITING

    Villeurbanne, 69100, France

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