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Can a new MRI scan reveal the Brain's hidden repair process in MS?

NCT ID NCT03600779

Recruiting now Knowledge-focused Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study tests whether a new MRI technique, called inhomogeneous Magnetisation Transfer (ihMT), can accurately measure myelin damage and repair in people with multiple sclerosis (MS). The researchers will compare ihMT scans with standard MRI measures in 85 adults with early-stage MS and healthy controls. The goal is to see if ihMT can serve as a reliable biomarker for monitoring the disease and the effects of future remyelinating therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
inhomogeneous Magnetisation Transfer (ihMT) MRI sequence
What this could lead to
If successful, this could provide a way to see myelin damage and repair in real time, helping to monitor MS and evaluate future remyelinating therapies.
What could go wrong
This is an early imaging study, not a treatment trial. The technique may not prove sensitive enough or may not translate into routine clinical use.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCLEROSIS, MULTIPLE

Contacts and locations

Locations

  • Assistance Publique Des Hotipaux de Marseille

    RECRUITING

    Marseille, PACA, 13354, France

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