New trial tests antibiotic to cut C-Section infections
NCT ID NCT06605118
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial is testing whether adding a single dose of azithromycin to standard antibiotics can prevent infections in 8,000 women having scheduled C-sections. Participants receive either azithromycin or a placebo, plus usual care. The study tracks infections like wound infections, endometritis, and sepsis up to 6 weeks after delivery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- azithromycin
- What this could lead to
- If it works, this could reduce the risk of serious infections after scheduled C-sections, making recovery safer for mothers.
- What could go wrong
- This is a large trial, but azithromycin may not lower infection rates beyond standard care, and overuse could contribute to antibiotic resistance.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Brown Univeristy
RECRUITINGProvidence, Rhode Island, 02905, United States
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Case Western Reserve University
RECRUITINGCleveland, Ohio, 44109, United States
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Columbia University
RECRUITINGNew York, New York, 10032, United States
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Duke University
RECRUITINGDurham, North Carolina, 27710, United States
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Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Magee Women's Hospital
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
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Regents of the University of California San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Alabama - Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
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University of North Carolina - Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Texas - Houston
RECRUITINGHouston, Texas, 77030, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84132, United States
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Finger sensor may read pain and anxiety during c-section
- Eye reflex may flag hidden risk in cesarean births
- Could adding oxytocin speed up labor induction after a C-Section?
- Massive trial tests cheap drug to stop Post-C-Section hemorrhage
- Can a video calm nerves before a C-Section better than a chat?
- C-Section spinal dose study: more drug may not mean more numbness