Can tighter blood pressure control in pregnancy prevent serious complications?

NCT ID NCT07746271

Not yet recruiting Disease control Sponsor: The George Washington University Biostatistics Center Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly assigned to one of the two blood pressure goals. The study tracks whether the stricter goal reduces a combined set of serious outcomes, including organ damage, early delivery, fetal or infant death, and placental abruption.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Antihypertensive medication (labetalol or nifedipine ER) titrated to a blood pressure goal of <140/90 mmHg
What this could lead to: If tighter blood pressure control works, it could reduce serious pregnancy complications like preterm birth and organ damage in women with gestational hypertension or preeclampsia.
What could go wrong: The trial is large but open-label, and the tighter goal may increase side effects from medication without improving outcomes. Results are not yet available.

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Conditions

The condition(s) this trial relates to.

hypertension, pregnancy-induced mild pre-eclampsia preeclampsia pregnancy disorder Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION IN PREGNANCY OBSTETRICAL COMPLICATIONS

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Brown Univeristy

Providence, Rhode Island, 02905, United States
Case Western Reserve University

Cleveland, Ohio, 44109, United States
Columbia University

New York, New York, 10032, United States
Duke University

Durham, North Carolina, 27710, United States
Magee Women's Hospital

Pittsburgh, Pennsylvania, 15213, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ohio State University

Columbus, Ohio, 43210, United States
Regents of the University of California San Francisco

San Francisco, California, 94143, United States
University of Alabama - Birmingham

Birmingham, Alabama, 35233, United States
University of North Carolina - Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Texas - Houston

Houston, Texas, 77030, United States
University of Utah

Salt Lake City, Utah, 84132, United States

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