Massive trial tests cheap drug to stop Post-C-Section hemorrhage

NCT ID NCT03364491

Completed Prevention Sponsor: The George Washington University Biostatistics Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large study tested whether giving tranexamic acid (TXA) during C-sections can prevent severe bleeding. Over 11,000 women received either TXA or a placebo right after delivery. The goal was to see if TXA reduces the need for blood transfusions or death. Results could change how doctors manage bleeding risks in cesarean births.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tranexamic acid (TXA)
What this could lead to: If effective, this could make C-sections safer by reducing the need for blood transfusions and preventing severe bleeding.
What could go wrong: This trial is complete, but results may not apply to all women. TXA carries a small risk of blood clots, which was monitored closely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hemorrhage obstetric disorder pregnancy disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMORRHAGE LABOR AND DELIVERY OBSTETRICAL COMPLICATIONS

Contacts and locations

Locations

Brown University

Providence, Rhode Island, 02905, United States
Case Western Reserve-MetroHealth

Cleveland, Ohio, 44109, United States
Columbia University

New York, New York, 10032, United States
Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Magee Women's Hospital of UPMC

Pittsburgh, Pennsylvania, 15213, United States
Northwestern University-Prentice Hospital

Chicago, Illinois, 60611, United States
Ohio State University Hospital

Columbus, Ohio, 43210, United States
University of Alabama - Birmingham

Birmingham, Alabama, 35233, United States
University of North Carolina - Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Texas - Houston

Houston, Texas, 77030, United States
University of Texas Medical Branch

Galveston, Texas, 77555, United States
University of Utah Medical Center

Salt Lake City, Utah, 84132, United States

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