HEMORRHAGE

This study compares two products used to stop mild to moderate bleeding during surgery: TachoSil and Surgicel. About 116 adults having open abdominal, chest, or pelvic surgery will be randomly assigned to receive one of the two. The main goal is to see which one stops bleeding fa…

This study tests whether giving tranexamic acid (TXA) before a second-trimester dilation and evacuation (D&E) procedure can reduce heavy bleeding. Heavy bleeding is a rare but serious risk of D&E. The trial will include 276 pregnant people aged 18 and older who are between 18 and…

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

This study tests a liquid agent called Onyx™ that is injected into arteries to block active bleeding outside the heart and brain. It includes 119 adults with severe bleeding from trauma, ulcers, or other causes. The goal is to see if it safely stops bleeding without needing furth…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study tests whether giving a clotting protein called factor XIII early can reduce blood loss in women with heavy bleeding after childbirth. About 988 women having a vaginal delivery will be randomly assigned to receive either factor XIII plus standard care or standard care a…

This study tests a new method called U-CaVIT, which uses a balloon placed in the uterus to prevent severe bleeding after a C-section in women at high risk. About 70 participants will either get standard care or standard care plus the balloon. The goal is to see if the balloon red…

This study tests whether intensive oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with small to medium bleeds will be randomly assigned to receive either standard care or enhanced mouth care plus antibiotic…

This study tests a non-invasive light-based device to measure blood flow and oxygen use in the brains of premature infants who have bleeding or fluid buildup. Researchers will compare these measurements in affected babies, those with other types of fluid buildup, and healthy newb…

This study aims to create a whole blood substitute by combining artificial oxygen carriers, plasma, and platelets. Researchers will test these mixtures in the lab using blood from 250 healthy volunteers to see if they can match the performance of real blood. The goal is to have a…

This study looks at 30 infants (3-8 months old) having surgery for craniosynostosis, a condition where skull bones fuse too early. Researchers want to see if a new monitoring method (PRAM) can better track blood pressure and fluid loss than standard monitors. The goal is to impro…