HEMORRHAGE

This study tests whether giving calcium before arriving at the hospital and vasopressin early in the hospital can help people with severe bleeding after a traumatic injury. About 1,050 participants will receive either the drugs or a placebo. The main goal is to see if these treat…

This study tests a special liquid called Onyx™ that hardens into a gel to stop active bleeding in arteries outside the brain and heart. About 119 adults with bleeding from trauma, ulcers, or other causes will receive this treatment. The goal is to see if it safely stops bleeding …

This study tests whether giving a clotting protein called factor XIII early can reduce blood loss in women with heavy bleeding after vaginal delivery. About 988 women in Switzerland will take part. If bleeding continues past a certain point, half receive the factor plus standard …

This study looks at whether people with atrial fibrillation can safely take a lower dose of the blood thinner apixaban for just 3 months after a procedure to close a part of the heart (left atrial appendage), then stop all blood thinners. The goal is to see if this approach reduc…

This study tests whether a product called TachoSil works better than Surgicel to stop mild to moderate bleeding during surgery. About 116 adults having open abdominal, pelvic, chest, or certain transplant surgeries will take part. The main goal is to see if TachoSil stops bleedin…

This study tests whether improved oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with a small to medium-sized bleed will be randomly assigned to receive either standard care or enhanced mouth care plus anti…

This study tests a special balloon device (U-CaVIT) placed inside the uterus during C-section to prevent severe bleeding in women at high risk. About 70 women will be randomly assigned to receive either standard care or standard care plus the balloon. The goal is to see if the ba…

This study tests a device called Mostcare® that uses blood pressure readings to predict whether critically ill children need more fluids. About 100 children aged 0-10 who are on breathing machines after surgery or trauma will take part. The goal is to see if the device's measurem…

This study looks at how to better track blood pressure and fluid loss in babies (3-8 months old) having skull surgery for craniosynostosis. Researchers will compare standard monitoring with a newer method called PRAM to see which gives a clearer picture of the baby's condition du…

This study tests a non-invasive light-based device to monitor brain blood flow and oxygen use in premature infants who have had a brain bleed or developed fluid buildup. Researchers will compare these infants to healthy newborns and those with other causes of fluid buildup. The g…

This study aims to create a complete artificial blood substitute that can be used when real blood is not available. Researchers will combine lab-made oxygen carriers, plasma, and platelets to mimic natural whole blood. The work is done in the lab with 250 healthy adults providing…