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Can a common drug make abortion safer? new trial aims to find out

NCT ID NCT06820177

Recruiting now Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving tranexamic acid (TXA) before a second-trimester dilation and evacuation (D&E) procedure can reduce heavy bleeding. Heavy bleeding is a rare but serious risk of D&E. The trial will include 276 pregnant people aged 18 and older who are between 18 and 24 weeks pregnant and are having an abortion or managing a fetal demise. Half will receive TXA, and half will receive a placebo, and researchers will compare bleeding outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tranexamic acid
What this could lead to
If it works, this could provide a simple, low-cost way to reduce bleeding complications during second-trimester abortion procedures.
What could go wrong
This is a Phase 4 trial, but it is still recruiting and results are not yet known. The drug may not significantly reduce bleeding or the need for extra interventions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Dilatation, Pathologic Hemorrhage pregnancy loss, recurrent, susceptibility to, 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABORTION BLOOD LOSS DILATION AND EVACUATION HEMORRHAGE PROPHYLACTIC TRANEXAMIC ACID USE

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Planned Parenthood of the Pacific Southwest

    RECRUITING

    San Diego, California, 92101, United States

    Contact Email: •••••@•••••

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of California San Diego

    RECRUITING

    San Diego, California, 92037, United States

    Contact Email: •••••@•••••

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