Liquid plug could stop bleeding without surgery

NCT ID NCT06742801

Recruiting now Disease control Sponsor: Medtronic Endovascular Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests a liquid agent called Onyx™ that is injected into arteries to block active bleeding outside the heart and brain. It includes 119 adults with severe bleeding from trauma, ulcers, or other causes. The goal is to see if it safely stops bleeding without needing further procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Onyx™ Liquid Embolic System (a liquid agent injected to block bleeding arteries)
What this could lead to: If successful, this could provide a safe and effective way to stop severe bleeding in trauma or ulcers without surgery.
What could go wrong: This is an early-stage study with only 119 participants. The treatment may fail to stop bleeding or cause unintended blockages. Long-term safety is not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Gastrointestinal Hemorrhage Hemorrhage injury ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GI BLEED HEMORRHAGE PERIPHERAL ARTERIAL HEMORRHAGE TRAUMA ULCER

Contacts and locations

Locations

Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
CHI Health Creighton University Medical Center-Bergan-Mercy
RECRUITING

Omaha, Nebraska, 68124, United States
Masschusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Phoenix, Arizona, 85054, United States
Rutgers New Jersey Medical School
SUSPENDED

Newark, New Jersey, 07103, United States
Stanford Medical Center
RECRUITING

Palo Alto, California, 94304, United States
The Mount Sinai
RECRUITING

New York, New York, 10029, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
Univ Of Texas Southwestern
RECRUITING

Dallas, Texas, 75235, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of California, Irvine
RECRUITING

Irvine, California, 92627, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37212, United States
Yale New Haven
RECRUITING

New Haven, Connecticut, 06510, United States

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