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Placental clues from a past pregnancy may guide treatment to prevent future complications

NCT ID NCT06004674

Recruiting now Disease control Sponsor: Endeavor Health Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This pilot trial tests whether using placental tissue analysis from a prior complicated pregnancy can guide treatment with the blood thinner enoxaparin to reduce the risk of recurrent adverse outcomes. The study enrolls women who had a previous pregnancy affected by early delivery, stillbirth, a small baby, or severe preeclampsia linked to a specific placental condition called maternal vascular malperfusion. Participants receive enoxaparin or standard care to see if it lowers the chance of similar problems in the next pregnancy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a blood thinner called enoxaparin (Lovenox)
What this could lead to
If it works, this approach could help prevent serious pregnancy complications like early delivery, stillbirth, or severe high blood pressure in women with a history of placental problems.
What could go wrong
This is a small pilot study with only 20 participants, so results may not apply broadly. Enoxaparin is a blood thinner and carries a risk of bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abortion, Spontaneous fetal growth restriction preeclampsia pregnancy disorder with abortive outcome Premature Birth severe pre-eclampsia Stillbirth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVERSE PREGNANCY OUTCOME

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • NorthShore University HealthSystem

    RECRUITING

    Evanston, Illinois, 60201, United States

    Contact

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