Could a daily aspirin save mothers and babies from hypertension risks?

NCT ID NCT04356326

Recruiting now Prevention Sponsor: Centre Hospitalier Intercommunal Creteil Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking 150 mg of aspirin daily, starting before 20 weeks of pregnancy, can prevent serious problems like preeclampsia, poor fetal growth, placental abruption, preterm birth, and death in pregnant women with chronic high blood pressure. About 500 women will be randomly assigned to receive either aspirin or a placebo. The goal is to find a safe, simple way to improve outcomes for both mother and baby.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin 150 mg daily
What this could lead to: If it works, this could offer a simple, low-cost way to prevent life-threatening complications like preeclampsia and preterm birth in pregnant women with chronic hypertension.
What could go wrong: This is a large Phase 3 trial, but aspirin may not reduce risks enough to change practice, and there is a small chance of side effects like bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

hypertension, pregnancy-induced Perinatal Death pregnancy disorder with abortive outcome fetal growth restriction prevention target placental abruption prevention target preeclampsia prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASPIRIN CHRONIC HYPERTENSION COMPLICATING PREGNANCY INTRAUTERINE GROWTH RESTRICTION PERINATAL DEATH PLACENTAL ABRUPTION PRE-ECLAMPSIA

Contacts and locations

Locations

CH Poissy
RECRUITING

Poissy, France
CHRU Lille
NOT_YET_RECRUITING

Lille, France
CHRU Nancy
WITHDRAWN

Nancy, France
CHU Antoine Béclère, AP-HP
RECRUITING

Clamart, France
CHU Bicêtre, AP-HP
RECRUITING

Le Kremlin-Bicêtre, France
CHU Bordeaux
RECRUITING

Bordeaux, France
CHU Caen
WITHDRAWN

Caen, 14000, France
CHU Cochin- Port Royal, AP-HP
RECRUITING

Paris, France
CHU Dijon
RECRUITING

Dijon, France
CHU Lyon
RECRUITING

Lyon, France
CHU Nantes
RECRUITING

Nantes, France
CHU Robert Débré, AP-HP
RECRUITING

Paris, France
CHU St Etienne
RECRUITING

Saint-Etienne, France
CHU Tenon
RECRUITING

Paris, France
CHU Toulouse
NOT_YET_RECRUITING

Toulouse, France
CHU Tours
WITHDRAWN

Tours, France
Centre Hospitalier Intercommunal de Créteil
RECRUITING

Créteil, 94000, France
Hôpital Louis Mourier, AP-HP
RECRUITING

Colombes, France
Hôpital St Joseph
WITHDRAWN

Marseille, France
Hôpital Trousseau, AP-HP
RECRUITING

Paris, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.